TY - GEN AB - This thesis focuses on acid‑sensing ion channels (ASICs), with particular attention to their mechanisms of activation and desensitization. ASICs are proton‑gated ion channels expressed throughout the nervous system. Although their precise physiological role remains unclear, they are thought to function as sensors of nociceptive signaling triggered by changes in extracellular pH. AD - Oregon Health and Science University AU - Cushman, Kenneth DA - 2007 DO - 10.6083/M4W95751 DO - DOI ID - 795 KW - Brain Ischemia KW - Signal Transduction KW - Sodium Channels KW - Stroke KW - Nervous System KW - Nociception KW - Acid Sensing Ion Channels L1 - https://digitalcollections.ohsu.edu/record/795/files/798_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/795/files/798_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/795/files/798_etd.pdf LK - https://digitalcollections.ohsu.edu/record/795/files/798_etd.pdf N2 - This thesis focuses on acid‑sensing ion channels (ASICs), with particular attention to their mechanisms of activation and desensitization. ASICs are proton‑gated ion channels expressed throughout the nervous system. Although their precise physiological role remains unclear, they are thought to function as sensors of nociceptive signaling triggered by changes in extracellular pH. PB - Oregon Health and Science University PY - 2007 T1 - Activation and desensitization of acid-sensing ion channels TI - Activation and desensitization of acid-sensing ion channels UR - https://digitalcollections.ohsu.edu/record/795/files/798_etd.pdf Y1 - 2007 ER -