TY  - GEN
AB  - CD8⁺ T cells play a central role in antiviral immunity by eliminating infected cells and establishing immune memory. While acute viral infections are typically cleared, herpesviruses such as herpes simplex virus‑1 (HSV‑1) evade complete elimination and establish lifelong persistence despite robust CD8⁺ T cell responses. This dissertation investigates the long‑term interaction between HSV‑1 infection and virus‑specific CD8⁺ T cell responses, as well as the broader impact of chronic viral infections on CD8⁺ T cell homeostasis. Using HSV‑1 and murine cytomegalovirus models, this work explores how persistent infection shapes lifelong antiviral immunity.
AD  - Oregon Health and Science University
AU  - Lang, Anna
DA  - 2007
DO  - 10.6083/M4V9863J
DO  - DOI
ED  - Nikolich, Janko
ED  - Advisor
ID  - 803
KW  - Mice
KW  - CD8-Positive T-Lymphocytes
KW  - Herpes Simplex
KW  - Herpesvirus 1, Human
KW  - Persistent Infection
KW  - Virus Diseases
KW  - Immunologic Memory
L1  - https://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf
N2  - CD8⁺ T cells play a central role in antiviral immunity by eliminating infected cells and establishing immune memory. While acute viral infections are typically cleared, herpesviruses such as herpes simplex virus‑1 (HSV‑1) evade complete elimination and establish lifelong persistence despite robust CD8⁺ T cell responses. This dissertation investigates the long‑term interaction between HSV‑1 infection and virus‑specific CD8⁺ T cell responses, as well as the broader impact of chronic viral infections on CD8⁺ T cell homeostasis. Using HSV‑1 and murine cytomegalovirus models, this work explores how persistent infection shapes lifelong antiviral immunity.
PB  - Oregon Health and Science University
PY  - 2007
T1  - The impact of lifelong viral infection on development and maintenance of memory CD8+ T cells
TI  - The impact of lifelong viral infection on development and maintenance of memory CD8+ T cells
UR  - https://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf
Y1  - 2007
ER  -