000000803 001__ 803
000000803 005__ 20260423115327.0
000000803 0247_ $$2DOI$$a10.6083/M4V9863J
000000803 037__ $$aETD
000000803 245__ $$aThe impact of lifelong viral infection on development and maintenance of memory CD8+ T cells
000000803 260__ $$bOregon Health and Science University
000000803 269__ $$a2007
000000803 336__ $$aDissertation
000000803 502__ $$bPh.D.
000000803 520__ $$aCD8⁺ T cells play a central role in antiviral immunity by eliminating infected cells and establishing immune memory. While acute viral infections are typically cleared, herpesviruses such as herpes simplex virus‑1 (HSV‑1) evade complete elimination and establish lifelong persistence despite robust CD8⁺ T cell responses. This dissertation investigates the long‑term interaction between HSV‑1 infection and virus‑specific CD8⁺ T cell responses, as well as the broader impact of chronic viral infections on CD8⁺ T cell homeostasis. Using HSV‑1 and murine cytomegalovirus models, this work explores how persistent infection shapes lifelong antiviral immunity.
000000803 540__ $$fCC BY
000000803 542__ $$fIn copyright - single owner
000000803 650__ $$aMice$$036842
000000803 650__ $$aCD8-Positive T-Lymphocytes$$030782
000000803 650__ $$aHerpes Simplex$$020156
000000803 650__ $$aHerpesvirus 1, Human$$030655
000000803 650__ $$aPersistent Infection$$013618
000000803 650__ $$aVirus Diseases$$027847
000000803 650__ $$aImmunologic Memory$$020713
000000803 691__ $$aSchool of Medicine$$041369
000000803 692__ $$aDepartment of Medicine$$041425
000000803 7001_ $$aLang, Anna$$uOregon Health and Science University$$041354
000000803 7201_ $$aNikolich, Janko$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000803 8564_ $$9847ed9f2-3779-41f2-a239-f30edbd75e72$$s3644790$$uhttps://digitalcollections.ohsu.edu/record/803/files/806_etd.pdf$$ePublic$$25d47a7966415d968ff3707c21804746d$$31
000000803 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000803 905__ $$a/rest/prod/nv/93/52/90/nv9352905
000000803 909CO $$ooai:digitalcollections.ohsu.edu:803$$pstudent-work
000000803 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000803 980__ $$aTheses and Dissertations