000008030 001__ 8030
000008030 005__ 20240124114256.0
000008030 0247_ $$2DOI$$a10.6083/2227mq170
000008030 037__ $$aETD
000008030 245__ $$aStudying the impact of infertility treatment, maternal diet and hyperandrogenemia on primate ovarian follicle, oocyte, and preimplantation embryo development
000008030 260__ $$bOregon Health and Science University
000008030 269__ $$a2020
000008030 336__ $$aDissertation
000008030 502__ $$bPh.D.
000008030 520__ $$aThe follicle is the structural unit within the ovary where endocrine-acting sex steroids and hormones are synthesized and the development of a mature oocyte capable of being fertilized occurs. It is comprised of the oocyte and the surrounding somatic cells, which includes primarily granulosa cells (GCs) and theca cells (TCs). The formation of a mature oocyte requires interactions with these somatic cells, either through direct or indirect means. Follicles initially appear in primates at mid-gestation, when there are approximately 7 million oocytes present in the fetal ovary, of which only 15-20% survive at the time of birth2,3. At this stage of development, oocytes reside in large nests of germ cells that are devoid of somatic cells. Each oocyte is subsequently enclosed by a flattened layer of GCs during the third trimester of pregnancy in primates, resulting in the formation of a primordial follicle. At birth, there is a fixed number of primordial follicles that defines the ovarian reserve and reproductive lifespan of an individual4-6. Thus, the primordial follicle pool serves as the source of all subsequent mature ovulatory follicles.
000008030 542__ $$fIn copyright - single owner
000008030 650__ $$aEmbryonic Development$$035917
000008030 650__ $$aDiet$$017776
000008030 650__ $$aOvarian Follicle$$019712
000008030 650__ $$aMetabolism$$022101
000008030 650__ $$aPolycystic Ovary Syndrome$$024369
000008030 6531_ $$awestern dietary patterns
000008030 6531_ $$ain vitro fertilization
000008030 691__ $$aSchool of Medicine$$041369
000008030 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000008030 7001_ $$aRavisankar, Sweta
000008030 8564_ $$91bb9a71c-8b78-41b1-b987-bfb2b7bda167$$s111048427$$uhttps://digitalcollections.ohsu.edu/record/8030/files/Ravisankar.Sweta.2020.pdf
000008030 905__ $$a/rest/prod/22/27/mq/17/2227mq170
000008030 909CO $$ooai:digitalcollections.ohsu.edu:8030$$pstudent-work
000008030 980__ $$aTheses and Dissertations