000008049 001__ 8049 000008049 005__ 20240124114257.0 000008049 0247_ $$2DOI$$a10.6083/qb98mg038 000008049 037__ $$aETD 000008049 245__ $$aLinear system analysis for photon-counting computed tomography protocol optimization 000008049 260__ $$bOregon Health and Science University 000008049 269__ $$a2020 000008049 336__ $$aDissertation 000008049 502__ $$bPh.D. 000008049 520__ $$aContrast-enhanced computed tomography (CT) has found widespread use as a diagnostic imaging tool, with contrast used in approximately 60% of all CT scans. Dual-Energy CT (DECT) offers improvements to standard CT contrast imaging, particularly through material differentiation which improves diagnostic criteria and makes virtual non-contrast imaging possible. Photon-Counting CT (PCCT) improves upon DECT with the use of multiple adjustable energy-thresholds. This technology promises better material differentiation, multi-contrast imaging, increased CNR, reduced dose for maintained image quality, and material-specific K-edge imaging, but optimization of PCCT protocols is needed in order to maximize these benefits. 000008049 542__ $$fIn copyright - single owner 000008049 6531_ $$atransmission computed tomography 000008049 691__ $$aSchool of Medicine$$041369 000008049 7001_ $$aLeary, Celeste I. 000008049 8564_ $$9fe5e514f-5bf4-4a7d-b262-3a748e5b181a$$s5395201$$uhttps://digitalcollections.ohsu.edu/record/8049/files/Leary.Celeste.2020.pdf 000008049 905__ $$a/rest/prod/qb/98/mg/03/qb98mg038 000008049 909CO $$ooai:digitalcollections.ohsu.edu:8049$$pstudent-work 000008049 980__ $$aTheses and Dissertations