000008063 001__ 8063
000008063 005__ 20240124114258.0
000008063 0247_ $$2DOI$$a10.6083/g732d957m
000008063 037__ $$aETD
000008063 245__ $$aThe role of radiation therapy in generating effective anti-tumor CD8+ T cell responses
000008063 260__ $$bOregon Health and Science University
000008063 269__ $$a2020
000008063 336__ $$aDissertation
000008063 502__ $$bPh.D.
000008063 520__ $$aEffective treatments for cancer have traditionally been divided into three separate arms: surgery, chemotherapy, and radiotherapy. Recently, however, a fourth arm, known as cancer immunotherapy, has been incorporated into treatment regimens and clinical trials with remarkable efficacy. These immunotherapies, designed to generate anticancer immune responses, have emphasized the importance of the immune system in controlling cancer and have placed greater focus on the the immune consequences of more traditional therapies. In this thesis, we have attempted to elucidate the way that radiotherapy can stimulate the interactions between the immune system, specifically CD8+ T cells, and cancer cells to induce lasting clearance of tumors.
000008063 542__ $$fIn copyright - single owner
000008063 650__ $$aImmunotherapy$$020724
000008063 650__ $$aRadiation$$025066
000008063 6531_ $$anatural killer t cell
000008063 6531_ $$amhc i molecules
000008063 6531_ $$acancer
000008063 691__ $$aSchool of Medicine$$041369
000008063 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008063 7001_ $$aZebertavage, Lauren K.
000008063 8564_ $$922e07643-9636-478a-9306-c203365077e2$$s3732705$$uhttps://digitalcollections.ohsu.edu/record/8063/files/Zebertavage.Lauren.2020.pdf
000008063 905__ $$a/rest/prod/g7/32/d9/57/g732d957m
000008063 909CO $$ooai:digitalcollections.ohsu.edu:8063$$pstudent-work
000008063 980__ $$aTheses and Dissertations