@article{ETD, recid = {8068}, author = {Amani, Mohammad F.}, title = {The role of intracellular Galectin-3 in the CD8 T cell response}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2020}, number = {ETD}, abstract = {The ability of tumors to induce immunosuppression and inhibit the cytolytic function of tumor-infiltrating lymphocytes (TIL) is a major obstacle to creating effective immunotherapies for cancer patients. The levels of galectin-3 (Gal-3) protein, which contribute to the immunosuppression, are increased during tumor progression in many cancers. Gal-3 contributes to immunosuppression by inducing M2 (wound healing) polarization of tumor-associated macrophages and playing a role in the survival and metastasis of cancer cells.}, url = {http://digitalcollections.ohsu.edu/record/8068}, doi = {https://doi.org/10.6083/j3860762v}, }