000008068 001__ 8068
000008068 005__ 20240124114258.0
000008068 0247_ $$2DOI$$a10.6083/j3860762v
000008068 037__ $$aETD
000008068 245__ $$aThe role of intracellular Galectin-3 in the CD8 T cell response
000008068 260__ $$bOregon Health and Science University
000008068 269__ $$a2020
000008068 336__ $$aDissertation
000008068 502__ $$bPh.D.
000008068 520__ $$aThe ability of tumors to induce immunosuppression and inhibit the cytolytic function of tumor-infiltrating lymphocytes (TIL) is a major obstacle to creating effective immunotherapies for cancer patients. The levels of galectin-3 (Gal-3) protein, which contribute to the immunosuppression, are increased during tumor progression in many cancers. Gal-3 contributes to immunosuppression by inducing M2 (wound healing) polarization of tumor-associated macrophages and playing a role in the survival and metastasis of cancer cells.
000008068 542__ $$fIn copyright - single owner
000008068 650__ $$aGalectin 3$$034835
000008068 650__ $$aImmunotherapy$$020724
000008068 650__ $$aImmunohistochemistry$$020708
000008068 6531_ $$acd8 positive t lymphocytes
000008068 6531_ $$aimmunology
000008068 6531_ $$at8 lymphocyte
000008068 691__ $$aSchool of Medicine$$041369
000008068 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000008068 7001_ $$aAmani, Mohammad F.
000008068 8564_ $$924c08ab5-2759-4adc-b834-113b25d99031$$s38161805$$uhttps://digitalcollections.ohsu.edu/record/8068/files/Amani.Mohammad.2020.pdf
000008068 905__ $$a/rest/prod/j3/86/07/62/j3860762v
000008068 909CO $$ooai:digitalcollections.ohsu.edu:8068$$pstudent-work
000008068 980__ $$aTheses and Dissertations