TY  - GEN
AB  - The goal of this dissertation is to define the molecular mechanisms underlying estrogen-mediated regulation of physiological homeostasis. Estrogen exerts both rapid and long-lasting effects in the central nervous system through complex interactions with multiple signaling pathways, making its mechanisms of action difficult to delineate. By identifying hypothalamic genes and signaling pathways regulated by estrogen, this work aims to clarify how estrogen integrates and coordinates diverse physiological processes. A deeper understanding of these molecular effects will inform the development of targeted therapeutic strategies for disorders affecting fertility and homeostatic regulation.
AD  - Oregon Health and Science University
AU  - Malyala, Anna
DA  - 2007
DO  - 10.6083/M46M34TF
DO  - DOI
ED  - Ronnekleiv, Oline
ED  - Mentor
ED  - Advisor
ID  - 808
KW  - Genetics
KW  - Physiology
KW  - Gene Expression Regulation
KW  - Hypothalamus
KW  - Estrogens
KW  - Phosphatidylinositol 3-Kinases
KW  - Signal Transduction
KW  - Central Nervous System
KW  - Receptors, Estrogen
L1  - https://digitalcollections.ohsu.edu/record/808/files/811_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/808/files/811_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/808/files/811_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/808/files/811_etd.pdf
N2  - The goal of this dissertation is to define the molecular mechanisms underlying estrogen-mediated regulation of physiological homeostasis. Estrogen exerts both rapid and long-lasting effects in the central nervous system through complex interactions with multiple signaling pathways, making its mechanisms of action difficult to delineate. By identifying hypothalamic genes and signaling pathways regulated by estrogen, this work aims to clarify how estrogen integrates and coordinates diverse physiological processes. A deeper understanding of these molecular effects will inform the development of targeted therapeutic strategies for disorders affecting fertility and homeostatic regulation.
PB  - Oregon Health and Science University
PY  - 2007
T1  - Hypothalamic gene expression and signal transduction effects of estrogen
TI  - Hypothalamic gene expression and signal transduction effects of estrogen
UR  - https://digitalcollections.ohsu.edu/record/808/files/811_etd.pdf
Y1  - 2007
ER  -