000008085 001__ 8085
000008085 005__ 20240124114259.0
000008085 0247_ $$2DOI$$a10.6083/9k41zf13m
000008085 037__ $$aETD
000008085 245__ $$aVisualizing the endothelial surface: imaging and other research techniques for studying the physiology of the endothelial-blood pool interface
000008085 260__ $$bOregon Health and Science University
000008085 269__ $$a2020
000008085 336__ $$aThesis
000008085 502__ $$bM.S.
000008085 520__ $$aWhile cardiovascular disease has been an area of significant research and clinical progress over the last few decades, it remains the leading cause of death worldwide and a substantial burden for both patients and healthcare providers. Nevertheless, medical advancements have drastically improved survival and quality of life across the range of cardiovascular pathologies, and imaging has played a key role in ushering in this improved standard of care. The diverse range of novel imaging modalities currently available for studying the heart and vasculature provides unique access to anatomy and physiology that would otherwise only be visible with surgical intervention and is at the center of both medical research and clinical practice. While many of the more common techniques visualize the heart and vessels from a macro perspective, there is less widespread use and familiarity with imaging techniques focused specifically on the endothelial surface, despite its massive importance in cardiovascular health and disease. The increasing number of options for imaging the endothelium and endothelial-blood pool interface as well as the need to simultaneously contextualize findings within the state of the entire cardiovascular system necessitates a comprehensive understanding of the various techniques that exist and how they can be used in a holistic fashion to uncover new pathways, evaluate novel therapeutics, and provide diagnostic information.
000008085 650__ $$aAtherosclerosis$$036329
000008085 650__ $$aEndothelium$$018439
000008085 650__ $$aMolecular Imaging$$038808
000008085 650__ $$avon Willebrand Factor$$027909
000008085 6531_ $$acardiac imaging technique
000008085 6531_ $$adiagnostic ultrasound
000008085 691__ $$aSchool of Medicine$$041369
000008085 692__ $$aDepartment of Biomedical Engineering$$041397
000008085 7001_ $$aBrown, Eran
000008085 8564_ $$910a5fe3b-29f0-4864-a312-0d5b1f47d1db$$s4634005$$uhttps://digitalcollections.ohsu.edu/record/8085/files/Brown.Eran.2020.pdf
000008085 905__ $$a/rest/prod/9k/41/zf/13/9k41zf13m
000008085 909CO $$ooai:digitalcollections.ohsu.edu:8085$$pstudent-work
000008085 980__ $$aTheses and Dissertations