000008091 001__ 8091 000008091 005__ 20250424233318.0 000008091 0247_ $$2DOI$$a10.6083/kh04dq40j 000008091 037__ $$aETD 000008091 245__ $$aA reward system polygenic risk score for predicting obesity and substance addiction 000008091 260__ $$bOregon Health and Science University 000008091 269__ $$a2020 000008091 336__ $$aDissertation 000008091 502__ $$bPh.D. 000008091 520__ $$aGenome-wide polygenic risk scores (PRS) can now predict complex genetic disease risk with nearly the same ability as tests for monogenic diseases. Despite this, there is no clear consensus how to incorporate PRS with other known modifiable and non-modifiable risk factors at the point of care. This challenge is further complicated by the fact that the most promising diseases for early PRS adoption (e.g., coronary artery disease, type 2 diabetes, and breast cancer) share many of the same modifiable risk factors - specifically, diet-induced obesity and drug use. Interestingly, the cause of these modifiable risk factors is at least partially genetic in most people. And while evidence for a common biological basis underlying nutrient intake and drug use in humans is growing, current clinical risk prediction models for complex genetic diseases have not incorporated any of this shared biology. 000008091 542__ $$fIn copyright - single owner 000008091 650__ $$aDiet$$017776 000008091 650__ $$aPrecision Medicine$$038927 000008091 650__ $$aPoint-of-Care Systems$$031352 000008091 650__ $$aObesity$$023118 000008091 650__ $$aSubstance-Related Disorders$$032029 000008091 650__ $$aGenome-Wide Association Study$$038168 000008091 691__ $$aSchool of Medicine$$041369 000008091 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422 000008091 7001_ $$aStevens, Kristen$$uOregon Health and Science University$$041354$$10000-0001-6425-4913 000008091 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eMentor 000008091 8564_ $$94460d559-5041-419e-987e-d42710fe3335$$s1397822$$uhttps://digitalcollections.ohsu.edu/record/8091/files/Stevens.Kristen.2020.pdf$$ePublic$$207b1856f94df67bc9e2d4daa47f92d79$$31 000008091 905__ $$a/rest/prod/kh/04/dq/40/kh04dq40j 000008091 909CO $$ooai:digitalcollections.ohsu.edu:8091$$pstudent-work 000008091 980__ $$aBiomedical Informatics