000000810 001__ 810
000000810 005__ 20260421142921.0
000000810 0247_ $$2DOI$$a10.6083/M4Z31WPN
000000810 037__ $$aETD
000000810 245__ $$aIndividual differences in cortical glutamate based on locomotor activity in a novel environment
000000810 260__ $$bOregon Health and Science University
000000810 269__ $$a2007
000000810 336__ $$aThesis
000000810 502__ $$bM.S.
000000810 502__ $$gBehavioral & Systems Neuroscience
000000810 520__ $$aLocomotor activity in a novel environment predicts vulnerability to drug abuse, yet genetic and environmental influences remain unclear. Using inbred C57BL/6J mice, this thesis examined environmental contributions to individual differences in novelty-induced locomotion. Mice were classified as high responders (HR) or low responders (LR) and compared across neurochemical and hormonal measures. HRs and LRs showed distinct regulation of medial prefrontal cortex glutamate, differing in presynaptic and extracellular glutamate responses, including differential sensitivity to repeated phencyclidine administration. In contrast, corticosterone responses to novelty did not differ between groups. These findings indicate that novelty-induced locomotor differences are linked to glutamatergic regulation rather than stress reactivity.
000000810 540__ $$fCC BY
000000810 542__ $$fIn copyright - single owner
000000810 650__ $$aIndividuality$$020758
000000810 650__ $$aGlutamic Acid$$031020
000000810 650__ $$aMicrodialysis$$030059
000000810 650__ $$aPhencyclidine$$023931
000000810 650__ $$aMicroscopy$$022282
000000810 650__ $$aPrefrontal Cortex$$029938
000000810 650__ $$aGlutamates$$019605
000000810 650__ $$aSubstance-Related Disorders$$032029
000000810 650__ $$aMice, Inbred C57BL$$022241
000000810 650__ $$aMice$$036842
000000810 650__ $$aLocomotion$$021605
000000810 650__ $$aStress, Physiological$$026467
000000810 691__ $$aSchool of Medicine$$041369
000000810 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000810 7001_ $$aMcCarthy, Kristin$$uOregon Health and Science University$$041354
000000810 7201_ $$aMeshul, Charles$$uOregon Health and Science University$$041354$$7Personal$$eChair
000000810 8564_ $$9fe1edbca-1a76-4d15-9ec4-5343d96bf38b$$s1913313$$uhttps://digitalcollections.ohsu.edu/record/810/files/813_etd.pdf$$ePublic$$27bc9a44e9d70f9845919dc36ec639854$$31
000000810 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000810 905__ $$a/rest/prod/2z/10/wq/23/2z10wq237
000000810 909CO $$ooai:digitalcollections.ohsu.edu:810$$pstudent-work
000000810 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000810 980__ $$aTheses and Dissertations