TY  - THES
AB  - This study examined the effects of repeated ethanol intoxication and withdrawal on withdrawal severity and voluntary alcohol consumption in Withdrawal Seizure‑Prone (WSP) and Withdrawal Seizure‑Resistant (WSR) mice. Using vapor inhalation to produce single or multiple withdrawal histories, repeated ethanol withdrawals produced a kindling‑like increase in handling‑induced convulsions in both lines. Withdrawal history also influenced drinking behavior, as WSR mice consumed more ethanol overall, but multiple withdrawals reduced voluntary intake in this line. These findings suggest shared genetic influences on withdrawal severity and alcohol drinking behavior.
AD  - Oregon Health and Science University
AU  - Baca, Gloria
DA  - 2006
DO  - 10.6083/M49C6VDD
DO  - DOI
ED  - Belknap, John
ED  - Mentor
ID  - 815
KW  - Substance Withdrawal Syndrome
KW  - Alcohol Withdrawal Seizures
KW  - Alcohol Drinking
KW  - Mice
KW  - Seizures
KW  - Alcoholic Intoxication
KW  - Alcoholism
KW  - kindling
L1  - https://digitalcollections.ohsu.edu/record/815/files/818_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/815/files/818_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/815/files/818_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/815/files/818_etd.pdf
N2  - This study examined the effects of repeated ethanol intoxication and withdrawal on withdrawal severity and voluntary alcohol consumption in Withdrawal Seizure‑Prone (WSP) and Withdrawal Seizure‑Resistant (WSR) mice. Using vapor inhalation to produce single or multiple withdrawal histories, repeated ethanol withdrawals produced a kindling‑like increase in handling‑induced convulsions in both lines. Withdrawal history also influenced drinking behavior, as WSR mice consumed more ethanol overall, but multiple withdrawals reduced voluntary intake in this line. These findings suggest shared genetic influences on withdrawal severity and alcohol drinking behavior.
PB  - Oregon Health and Science University
PY  - 2006
T1  - Kindling by repeated alcohol dependence and withdrawal experiences: effects on handling-induced convulsions and voluntary alcohol drinking in ethanol withdrawal seizure -prone and -resistant mouse selected lines
TI  - Kindling by repeated alcohol dependence and withdrawal experiences: effects on handling-induced convulsions and voluntary alcohol drinking in ethanol withdrawal seizure -prone and -resistant mouse selected lines
UR  - https://digitalcollections.ohsu.edu/record/815/files/818_etd.pdf
Y1  - 2006
ER  -