TY  - GEN
AB  - This dissertation identifies novel roles for the insulin-like growth factor (IGF) system and cathepsin B in Kaposi sarcoma–associated herpesvirus (KSHV)-mediated tumorigenesis. Using a physiologically relevant tissue culture model of KSHV-infected endothelial cells and global transcriptional profiling, key components of the IGF system—including IGFBP-1, -2, and -6, the insulin receptor, and the IGF-II receptor—were found to be dysregulated and functionally important in Kaposi sarcoma. Additionally, cathepsin B was shown to regulate tumor invasion, and a previously unrecognized functional link between the IGF-II receptor and cathepsin B was identified as essential for KSHV-driven tumorigenesis. These findings reveal new mechanisms underlying Kaposi sarcoma and suggest potential therapeutic targets.
AD  - Oregon Health and Science University
AU  - Rose, Patrick
DA  - 2007
DO  - 10.6083/M4SB43R1
DO  - DOI
ED  - Fruh, Klaus
ED  - Advisor
ED  - Mentor
ID  - 819
KW  - Cathepsin B
KW  - Insulin-Like Growth Factor II
KW  - Insulin
KW  - Insulin-Like Growth Factor Binding Protein 1
KW  - Carcinogenesis
KW  - Herpesvirus 8, Human
KW  - Receptor, IGF Type 2
KW  - Sarcoma, Kaposi
L1  - https://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf
N2  - This dissertation identifies novel roles for the insulin-like growth factor (IGF) system and cathepsin B in Kaposi sarcoma–associated herpesvirus (KSHV)-mediated tumorigenesis. Using a physiologically relevant tissue culture model of KSHV-infected endothelial cells and global transcriptional profiling, key components of the IGF system—including IGFBP-1, -2, and -6, the insulin receptor, and the IGF-II receptor—were found to be dysregulated and functionally important in Kaposi sarcoma. Additionally, cathepsin B was shown to regulate tumor invasion, and a previously unrecognized functional link between the IGF-II receptor and cathepsin B was identified as essential for KSHV-driven tumorigenesis. These findings reveal new mechanisms underlying Kaposi sarcoma and suggest potential therapeutic targets.
PB  - Oregon Health and Science University
PY  - 2007
T1  - Mechanisms of Kaposi sarcoma-associated herpesvirus induced tumorigenesis
TI  - Mechanisms of Kaposi sarcoma-associated herpesvirus induced tumorigenesis
UR  - https://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf
Y1  - 2007
ER  -