000000819 001__ 819
000000819 005__ 20260421152257.0
000000819 0247_ $$2DOI$$a10.6083/M4SB43R1
000000819 037__ $$aETD
000000819 245__ $$aMechanisms of Kaposi sarcoma-associated herpesvirus induced tumorigenesis
000000819 260__ $$bOregon Health and Science University
000000819 269__ $$a2007
000000819 336__ $$aDissertation
000000819 502__ $$bPh.D.
000000819 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000000819 520__ $$aThis dissertation identifies novel roles for the insulin-like growth factor (IGF) system and cathepsin B in Kaposi sarcoma–associated herpesvirus (KSHV)-mediated tumorigenesis. Using a physiologically relevant tissue culture model of KSHV-infected endothelial cells and global transcriptional profiling, key components of the IGF system—including IGFBP-1, -2, and -6, the insulin receptor, and the IGF-II receptor—were found to be dysregulated and functionally important in Kaposi sarcoma. Additionally, cathepsin B was shown to regulate tumor invasion, and a previously unrecognized functional link between the IGF-II receptor and cathepsin B was identified as essential for KSHV-driven tumorigenesis. These findings reveal new mechanisms underlying Kaposi sarcoma and suggest potential therapeutic targets.
000000819 540__ $$fCC BY
000000819 542__ $$fIn copyright - single owner
000000819 650__ $$aCathepsin B$$016227
000000819 650__ $$aInsulin-Like Growth Factor II$$020879
000000819 650__ $$aInsulin$$020872
000000819 650__ $$aInsulin-Like Growth Factor Binding Protein 1$$031243
000000819 650__ $$aCarcinogenesis$$040251
000000819 650__ $$aHerpesvirus 8, Human$$031505
000000819 650__ $$aReceptor, IGF Type 2$$030040
000000819 650__ $$aSarcoma, Kaposi$$025716
000000819 691__ $$aSchool of Medicine$$041369
000000819 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000819 7001_ $$aRose, Patrick$$uOregon Health and Science University$$041354
000000819 7201_ $$aFruh, Klaus$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000819 8564_ $$995ebed73-736f-49a1-9589-b8daf72ef23f$$s5822212$$uhttps://digitalcollections.ohsu.edu/record/819/files/822_etd.pdf$$ePublic$$23d6046d584c6b260fe0d96f0cb7483e1$$31
000000819 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000819 905__ $$a/rest/prod/ns/06/46/04/ns0646043
000000819 909CO $$ooai:digitalcollections.ohsu.edu:819$$pstudent-work
000000819 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000819 980__ $$aTheses and Dissertations