000000822 001__ 822
000000822 005__ 20260421144853.0
000000822 0247_ $$2DOI$$a10.6083/M4D50K09
000000822 037__ $$aETD
000000822 245__ $$aInhibition of CD8 T cell effector functions by murine cytomegalovirus immune evasion genes
000000822 260__ $$bOregon Health and Science University
000000822 269__ $$a2007
000000822 336__ $$aDissertation
000000822 502__ $$bPh.D.
000000822 520__ $$aMurine cytomegalovirus (MCMV) encodes three immune evasion genes (m04, m06, and m152) that interfere with MHC class I antigen presentation to CD8 T cells. Although not required for viral persistence, these genes are evolutionarily conserved, suggesting an important role in immune modulation. This dissertation characterizes the individual and combined effects of these immune evasion genes on antigen-specific CD8 T cell responses. Coordinated expression of all three genes potently inhibits CD8 T cell–mediated killing of infected cells, whereas loss of any single gene partially restores lysis. The findings demonstrate that reduced total MHC class I levels, rather than complete absence of cognate peptide, weaken T cell–target interactions and impair effective cytotoxic responses, revealing a key mechanism by which MCMV evades antiviral immunity.
000000822 540__ $$fCC BY
000000822 542__ $$fIn copyright - single owner
000000822 650__ $$aImmunity, Active$$020669
000000822 650__ $$aMuromegalovirus$$030544
000000822 650__ $$aCD8-Positive T-Lymphocytes$$030782
000000822 650__ $$aGenetics$$019472
000000822 650__ $$aImmune Evasion$$038852
000000822 650__ $$aAllergy and Immunology$$014456
000000822 691__ $$aSchool of Medicine$$041369
000000822 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000822 7001_ $$aPinto, Amelia$$uOregon Health and Science University$$041354
000000822 7201_ $$aHill, Ann$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000822 8564_ $$93e0ea365-4e59-48f2-bc06-5d63d891b3e4$$s3048054$$uhttps://digitalcollections.ohsu.edu/record/822/files/825_etd.pdf$$ePublic$$24a7bda06547085c898d18a50a3d184d5$$31
000000822 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000822 905__ $$a/rest/prod/r2/07/tp/37/r207tp37s
000000822 909CO $$ooai:digitalcollections.ohsu.edu:822$$pstudent-work
000000822 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000822 980__ $$aTheses and Dissertations