TY  - GEN
N2  - Destruction of skeletal muscle (rhabdomyolysis) releases myoglobin, causing rhabdomyolysis-induced acute renal injury (rhAKI). As rhAKI commonly occurs in austere environments such as earthquakes and armed conflict, supportive care is challenging. Specific therapy would be a significant advance. Since myoglobin is taken into renal tubular cells via the renal cortex-specific transporter megalin (LRP2), we hypothesized that interfering with megalin would ameliorate rhAKI.
DO  - 10.6083/ks65hc833
DO  - DOI
AB  - Destruction of skeletal muscle (rhabdomyolysis) releases myoglobin, causing rhabdomyolysis-induced acute renal injury (rhAKI). As rhAKI commonly occurs in austere environments such as earthquakes and armed conflict, supportive care is challenging. Specific therapy would be a significant advance. Since myoglobin is taken into renal tubular cells via the renal cortex-specific transporter megalin (LRP2), we hypothesized that interfering with megalin would ameliorate rhAKI.
AD  - OHSU, PVAMC
AD  - OHSU, PVAMC
AD  - OHSU, PVAMC
AD  - OHSU, PVAMC
AD  - OHSU, PVAMC
T1  - Proximal tubule megalin inhibition prevents acute kidney injury due to rhabdomyolysis in mice
DA  - 2020
AU  - Hutchens, Michael
AU  - Matsushita, Katsuyuki
AU  - Eiwaz, Mahaba
AU  - Saritas, Turgay
AU  - McCormick, Jim
L1  - https://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8224
L4  - https://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
KW  - Acute Kidney Injury
KW  - Rhabdomyolysis
KW  - Low Density Lipoprotein Receptor-Related Protein-2
KW  - Kidney Diseases
KW  - megalin
KW  - rhabdomyolysis-induced acute renal injury
KW  - kidney trauma
TI  - Proximal tubule megalin inhibition prevents acute kidney injury due to rhabdomyolysis in mice
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
LK  - https://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
UR  - https://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
ER  -