000008224 001__ 8224
000008224 005__ 20240129155649.0
000008224 0247_ $$2DOI$$a10.6083/ks65hc833
000008224 037__ $$aIR
000008224 245__ $$aProximal tubule megalin inhibition prevents acute kidney injury due to rhabdomyolysis in mice
000008224 260__ $$bOregon Health and Science University
000008224 269__ $$a2020
000008224 336__ $$aAbstract
000008224 520__ $$aDestruction of skeletal muscle (rhabdomyolysis) releases myoglobin, causing rhabdomyolysis-induced acute renal injury (rhAKI). As rhAKI commonly occurs in austere environments such as earthquakes and armed conflict, supportive care is challenging. Specific therapy would be a significant advance. Since myoglobin is taken into renal tubular cells via the renal cortex-specific transporter megalin (LRP2), we hypothesized that interfering with megalin would ameliorate rhAKI.
000008224 540__ $$fCC BY
000008224 542__ $$fIn copyright - joint owners
000008224 650__ $$aAcute Kidney Injury$$039113
000008224 650__ $$aRhabdomyolysis$$025427
000008224 650__ $$aLow Density Lipoprotein Receptor-Related Protein-2$$033284
000008224 650__ $$aKidney Diseases$$021191
000008224 6531_ $$amegalin
000008224 6531_ $$arhabdomyolysis-induced acute renal injury
000008224 6531_ $$akidney trauma
000008224 691__ $$aSchool of Medicine$$041369
000008224 692__ $$aDepartment of Anesthesiology and Perioperative Medicine$$041393
000008224 7001_ $$aHutchens, Michael$$uOHSU, PVAMC$$041348
000008224 7001_ $$aMatsushita, Katsuyuki$$uOHSU, PVAMC$$041348
000008224 7001_ $$aEiwaz, Mahaba$$uOHSU, PVAMC$$041348
000008224 7001_ $$aSaritas, Turgay$$uOHSU, PVAMC$$041348
000008224 7001_ $$aMcCormick, Jim$$uOHSU, PVAMC$$041348
000008224 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008224 8564_ $$945370e46-3de1-4d20-ae5c-c9b84a6f117d$$s52904$$uhttps://digitalcollections.ohsu.edu/record/8224/files/Michael-Hutchens.pdf
000008224 905__ $$a/rest/prod/ks/65/hc/83/ks65hc833
000008224 980__ $$aResearch Week