TY  - GEN
N2  - PKU requires lifelong management, but the childhood PKU diet does not accommodate for post-adolescent patient variations, including: (1) the diet's effect on blood phenylalanine (Phe) concentrations, and (2) the therapeutic benefits of prescribed blood Phe targets. Most adult patients discontinue the inflexible diet, and are exposed to PKU's adverse effects. Research supports large neutral amino acids (LNAAs) as potential alternative strategy; we propose an additive LNAA strategy. We aim to evaluate the clinical efficacy of a combined treatment strategy: usual care (the PKU diet) with LNAA supplementation.
DO  - 10.6083/np1939959
DO  - DOI
AB  - PKU requires lifelong management, but the childhood PKU diet does not accommodate for post-adolescent patient variations, including: (1) the diet's effect on blood phenylalanine (Phe) concentrations, and (2) the therapeutic benefits of prescribed blood Phe targets. Most adult patients discontinue the inflexible diet, and are exposed to PKU's adverse effects. Research supports large neutral amino acids (LNAAs) as potential alternative strategy; we propose an additive LNAA strategy. We aim to evaluate the clinical efficacy of a combined treatment strategy: usual care (the PKU diet) with LNAA supplementation.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Large neutral amino acid supplementation improves clinical efficacy of usual care in adult PKU
DA  - 2020
AU  - Prince, Annie
AU  - Depenweiller, Maria
AU  - Chambers, Ash
AU  - Ahring, Kirsten
AU  - Moseley, Kathryn
AU  - Kumru, Burcu
L1  - https://digitalcollections.ohsu.edu/record/8244/files/Annie-Prince.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8244
L4  - https://digitalcollections.ohsu.edu/record/8244/files/Annie-Prince.pdf
KW  - Phenylketonurias
KW  - Nutrition Therapy
KW  - orphan products
KW  - amino acid supplementation
KW  - medical foods
KW  - inherited metabolic diseases
TI  - Large neutral amino acid supplementation improves clinical efficacy of usual care in adult PKU
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8244/files/Annie-Prince.pdf
LK  - https://digitalcollections.ohsu.edu/record/8244/files/Annie-Prince.pdf
UR  - https://digitalcollections.ohsu.edu/record/8244/files/Annie-Prince.pdf
ER  -