000000827 001__ 827 000000827 005__ 20260420120805.0 000000827 0247_ $$2DOI$$a10.6083/M4RB72MN 000000827 037__ $$aETD 000000827 245__ $$aBCR-ABL mutations in chronic myeloid leukemia patients 000000827 260__ $$bOregon Health and Science University 000000827 269__ $$a2007 000000827 336__ $$aDissertation 000000827 502__ $$bPh.D. 000000827 520__ $$aThe Bcr‑Abl tyrosine kinase drives chronic myeloid leukemia (CML) and is the target of imatinib therapy, which induces complete cytogenetic responses in most patients. However, relapse is often associated with acquired BCR‑ABL mutations. This dissertation examines kinase domain mutations in patients with stable responses, regulatory domain mutations outside the kinase domain, and catalytically inactive Bcr‑Abl deletion mutants. While mutations were frequent during imatinib treatment, their effects varied, with limited predictive value for relapse and diverse impacts on drug resistance and sensitivity. 000000827 540__ $$fCC BY 000000827 542__ $$fIn copyright - single owner 000000827 650__ $$aLeukemia$$021430 000000827 650__ $$aProtein-Tyrosine Kinases$$024762 000000827 650__ $$aAntineoplastic Agents$$014911 000000827 650__ $$aGenetics$$019472 000000827 650__ $$aDrug Therapy$$018086 000000827 650__ $$aFusion Proteins, bcr-abl$$028845 000000827 650__ $$aImatinib Mesylate$$011313 000000827 650__ $$aLeukemia, Myelogenous, Chronic, BCR-ABL Positive$$028428 000000827 650__ $$aMutation$$022555 000000827 691__ $$aSchool of Medicine$$041369 000000827 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399 000000827 7001_ $$aSherbenou, Daniel$$uOregon Health and Science University$$041354 000000827 7201_ $$aDruker, Brian$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor 000000827 7201_ $$aDeininger, Michael$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor 000000827 8564_ $$9540fed1d-d979-4629-b37b-e3423cf5be24$$s3457723$$uhttps://digitalcollections.ohsu.edu/record/827/files/830_etd.pdf$$ePublic$$2d0e66f3ec733697f75c5496c32b93591$$31 000000827 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p> 000000827 905__ $$a/rest/prod/xg/94/hp/58/xg94hp58h 000000827 909CO $$ooai:digitalcollections.ohsu.edu:827$$pstudent-work 000000827 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument 000000827 980__ $$aTheses and Dissertations