TY  - GEN
N2  - T-cell large granular lymphocytic leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder of mature cytotoxic T-cells. Accurate diagnosis relies on the integration of morphologic, immunophenotypic, molecular, and clinicopathologic findings. This study examined the frequency of abnormal findings in cases with clinical or hematopathologic suspicion for T-LGLL to investigate the relative importance of each diagnostic entity. This is a retrospective review of cases with clinical or hematopathologic suspicion for T-LGLL with concurrent flow cytometry, next-generation sequencing of STAT3/STAT5B, and T-cell receptor gene rearrangement (TCR) at a single academic institution from 2017-2019. Clinicopathologic information was abstracted from the chart.
DO  - 10.6083/td96k300z
DO  - DOI
AB  - T-cell large granular lymphocytic leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder of mature cytotoxic T-cells. Accurate diagnosis relies on the integration of morphologic, immunophenotypic, molecular, and clinicopathologic findings. This study examined the frequency of abnormal findings in cases with clinical or hematopathologic suspicion for T-LGLL to investigate the relative importance of each diagnostic entity. This is a retrospective review of cases with clinical or hematopathologic suspicion for T-LGLL with concurrent flow cytometry, next-generation sequencing of STAT3/STAT5B, and T-cell receptor gene rearrangement (TCR) at a single academic institution from 2017-2019. Clinicopathologic information was abstracted from the chart.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Diagnostic utility of molecular and flow cytometric findings in T-cell large granular lymphocytic leukemia
DA  - 2020
AU  - Raymond, Lauren
AU  - Fan, Guang
AU  - Dunlap, Jennifer
AU  - Press, Richard
AU  - Raess, Philipp W.
L1  - https://digitalcollections.ohsu.edu/record/8273/files/Raymond_Presentation.pdf
L1  - https://digitalcollections.ohsu.edu/record/8273/files/Lauren-Raymond.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8273
L4  - https://digitalcollections.ohsu.edu/record/8273/files/Raymond_Presentation.pdf
L4  - https://digitalcollections.ohsu.edu/record/8273/files/Lauren-Raymond.pdf
KW  - T-Lymphocytes
KW  - Genes, T-Cell Receptor
KW  - Leukemia, Large Granular Lymphocytic
KW  - Flow Cytometry
KW  - stat3 protein, human
KW  - hematopathology
TI  - Diagnostic utility of molecular and flow cytometric findings in T-cell large granular lymphocytic leukemia
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8273/files/Raymond_Presentation.pdf
L2  - https://digitalcollections.ohsu.edu/record/8273/files/Lauren-Raymond.pdf
LK  - https://digitalcollections.ohsu.edu/record/8273/files/Raymond_Presentation.pdf
LK  - https://digitalcollections.ohsu.edu/record/8273/files/Lauren-Raymond.pdf
UR  - https://digitalcollections.ohsu.edu/record/8273/files/Raymond_Presentation.pdf
UR  - https://digitalcollections.ohsu.edu/record/8273/files/Lauren-Raymond.pdf
ER  -