TY  - GEN
N2  - Pityriasis Rubra Pilaris (PRP) is a rare and debilitating cutaneous disease characterized by widespread red scaly plaques, follicular papules, and palmoplantar keratoderma. The pathogenesis of PRP is poorly understood, although overexpression of Th17 cytokines have been reported suggesting an inflammatory pathogenesis that may share features with psoriasis. In this study, we used OLINK proximity extension assay technology to quantitate 92 plasma inflammatory proteins of 11 PRP patients treated with ixekizumab (NCT03485976). To our knowledge, this is the first quantitative protein analysis of PRP. These findings support prior studies implicating dysregulation of the Th17 axis in PRP and may help elucidate relevant pathways to target and better treat PRP. Further research is warranted to compare samples to a control population, and to compare these systemic biomarkers to local changes in skin samples.
DO  - 10.6083/3j333284w
DO  - DOI
AB  - Pityriasis Rubra Pilaris (PRP) is a rare and debilitating cutaneous disease characterized by widespread red scaly plaques, follicular papules, and palmoplantar keratoderma. The pathogenesis of PRP is poorly understood, although overexpression of Th17 cytokines have been reported suggesting an inflammatory pathogenesis that may share features with psoriasis. In this study, we used OLINK proximity extension assay technology to quantitate 92 plasma inflammatory proteins of 11 PRP patients treated with ixekizumab (NCT03485976). To our knowledge, this is the first quantitative protein analysis of PRP. These findings support prior studies implicating dysregulation of the Th17 axis in PRP and may help elucidate relevant pathways to target and better treat PRP. Further research is warranted to compare samples to a control population, and to compare these systemic biomarkers to local changes in skin samples.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Differentially expressed plasma proteins in pityriasis rubra pilaris patients treated with ixekizumab
DA  - 2020
AU  - Strunck, Jennifer
AU  - Haynes, Dylan
AU  - Topham, Christina
AU  - Ortega, Alex
AU  - Greiling, Teri
L1  - https://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8282
L4  - https://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
KW  - Pityriasis Rubra Pilaris
KW  - Cytokines
KW  - Dermatology
KW  - Skin Diseases
KW  - ixekizumab
KW  - plasma proteins
KW  - protein analysis
TI  - Differentially expressed plasma proteins in pityriasis rubra pilaris patients treated with ixekizumab
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
LK  - https://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
UR  - https://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
ER  -