000008282 001__ 8282
000008282 005__ 20240403141809.0
000008282 0247_ $$2DOI$$a10.6083/3j333284w
000008282 037__ $$aIR
000008282 041__ $$aeng
000008282 245__ $$aDifferentially expressed plasma proteins in pityriasis rubra pilaris patients treated with ixekizumab
000008282 260__ $$bOregon Health and Science University
000008282 269__ $$a2020
000008282 336__ $$aAbstract
000008282 520__ $$aPityriasis Rubra Pilaris (PRP) is a rare and debilitating cutaneous disease characterized by widespread red scaly plaques, follicular papules, and palmoplantar keratoderma. The pathogenesis of PRP is poorly understood, although overexpression of Th17 cytokines have been reported suggesting an inflammatory pathogenesis that may share features with psoriasis. In this study, we used OLINK proximity extension assay technology to quantitate 92 plasma inflammatory proteins of 11 PRP patients treated with ixekizumab (NCT03485976). To our knowledge, this is the first quantitative protein analysis of PRP. These findings support prior studies implicating dysregulation of the Th17 axis in PRP and may help elucidate relevant pathways to target and better treat PRP. Further research is warranted to compare samples to a control population, and to compare these systemic biomarkers to local changes in skin samples.
000008282 540__ $$fCC BY
000008282 542__ $$fIn copyright - joint owners
000008282 650__ $$aPityriasis Rubra Pilaris$$024206
000008282 650__ $$aCytokines$$028964
000008282 650__ $$aDermatology$$017631
000008282 650__ $$aSkin Diseases$$026047
000008282 6531_ $$aixekizumab
000008282 6531_ $$aplasma proteins
000008282 6531_ $$aprotein analysis
000008282 691__ $$aSchool of Medicine$$041369
000008282 692__ $$aDepartment of Dermatology$$041406
000008282 7001_ $$aStrunck, Jennifer$$uOregon Health and Science University$$041354
000008282 7001_ $$aHaynes, Dylan$$uOregon Health and Science University$$041354
000008282 7001_ $$aTopham, Christina$$uOregon Health and Science University$$041354
000008282 7001_ $$aOrtega, Alex$$uOregon Health and Science University$$041354
000008282 7001_ $$aGreiling, Teri$$uOregon Health and Science University$$041354
000008282 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008282 8564_ $$9b0b457fc-03da-4883-a97d-52b0258064e6$$s48701$$uhttps://digitalcollections.ohsu.edu/record/8282/files/Jennifer-Strunck.pdf
000008282 905__ $$a/rest/prod/3j/33/32/84/3j333284w
000008282 980__ $$aResearch Week