TY  - GEN
N2  - The flavivirus Zika virus (ZIKV) has extensive human health impact yet lacks vaccines and antiviral treatments in part due to gaps in understanding of the its infectious cycle. To gain further insight into the infectious cycle without complete ablation of host or viral proteins we designed alpaca derived variable-heavy-chain antibody fragments (VHHs) against ZIKV. VHHs are encoded on a single gene, can be expressed in mammalian cells, and bind cognates in cytoplasm.
DO  - 10.6083/m326m233x
DO  - DOI
AB  - The flavivirus Zika virus (ZIKV) has extensive human health impact yet lacks vaccines and antiviral treatments in part due to gaps in understanding of the its infectious cycle. To gain further insight into the infectious cycle without complete ablation of host or viral proteins we designed alpaca derived variable-heavy-chain antibody fragments (VHHs) against ZIKV. VHHs are encoded on a single gene, can be expressed in mammalian cells, and bind cognates in cytoplasm.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Characterization of single-domain antibodies against Zika virus structural and non-structural proteins
ED  - Cebra, Christopher
ED  - Hirsch, Alec
ED  - Collaborator
ED  - Collaborator
DA  - 2020
AU  - Weinstein, Jules
AU  - Merutka, Ilaria
AU  - Tafesse, Fikadu
L1  - https://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8286
L4  - https://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
KW  - Zika Virus
KW  - Camelids, New World
KW  - zikv capsid protein
KW  - variable-heavy-chain antibody fragments
KW  - alpacas
TI  - Characterization of single-domain antibodies against Zika virus structural and non-structural proteins
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
LK  - https://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
UR  - https://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
ER  -