000008286 001__ 8286
000008286 005__ 20240328124300.0
000008286 0247_ $$2DOI$$a10.6083/m326m233x
000008286 037__ $$aIR
000008286 041__ $$aeng
000008286 245__ $$aCharacterization of single-domain antibodies against Zika virus structural and non-structural proteins
000008286 260__ $$bOregon Health and Science University
000008286 269__ $$a2020
000008286 336__ $$aAbstract
000008286 520__ $$aThe flavivirus Zika virus (ZIKV) has extensive human health impact yet lacks vaccines and antiviral treatments in part due to gaps in understanding of the its infectious cycle. To gain further insight into the infectious cycle without complete ablation of host or viral proteins we designed alpaca derived variable-heavy-chain antibody fragments (VHHs) against ZIKV. VHHs are encoded on a single gene, can be expressed in mammalian cells, and bind cognates in cytoplasm.
000008286 540__ $$fCC BY
000008286 542__ $$fIn copyright - joint owners
000008286 650__ $$aZika Virus$$011750
000008286 650__ $$aCamelids, New World$$016001
000008286 6531_ $$azikv capsid protein
000008286 6531_ $$avariable-heavy-chain antibody fragments
000008286 6531_ $$aalpacas
000008286 691__ $$aSchool of Medicine$$041369
000008286 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008286 7001_ $$aWeinstein, Jules$$uOregon Health and Science University$$041354
000008286 7001_ $$aMerutka, Ilaria$$uOregon Health and Science University$$041354
000008286 7001_ $$aTafesse, Fikadu$$uOregon Health and Science University$$041354
000008286 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008286 7201_ $$aCebra, Christopher$$uOregon State University$$eCollaborator$$7Personal
000008286 7201_ $$aHirsch, Alec$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal
000008286 8564_ $$9ee474ce3-c006-4266-8c0c-8c9dcf18404a$$s46146$$uhttps://digitalcollections.ohsu.edu/record/8286/files/Jules-Weinstein.pdf
000008286 905__ $$a/rest/prod/m3/26/m2/33/m326m233x
000008286 980__ $$aResearch Week