@article{IR, recid = {8288}, author = {Garimella, Sandilya and Li, Ailin and Harrilal, Chris and Ibrahim, Yehia M. and Smith, Richard D.}, title = {Mass and structural selective ion soft_landing for separation, collection and characterization of amyloid-beta peptide structures and their role in Alzheimer disease}, publisher = {Oregon Health and Science University}, address = {2020}, number = {IR}, abstract = {Advancements in ion mobility technology, particularly Structures for Lossless Ion Manipulations (SLIM), have enabled the detailed characterization of heterogeneity of biomolecular structures in a sample. SLIM enables the resolution of subtle variations of molecular structures (e.g. separation of conformations, isotopes, double bond positions, stereoisomers, isotopologues, isotopomers, etc.) which could be markers for diseases. SLIM also enables IMS separations with high resolution, high throughput, high ion utilization efficiency. In this work, we will present SLIM technology and its game-changing ability to perform analytical separations with unprecedented utility and precision.}, url = {http://digitalcollections.ohsu.edu/record/8288}, doi = {https://doi.org/10.6083/w3763757r}, }