TY  - GEN
AB  - Advancements in ion mobility technology, particularly Structures for Lossless Ion Manipulations (SLIM), have enabled the detailed characterization of heterogeneity of biomolecular structures in a sample. SLIM enables the resolution of subtle variations of molecular structures (e.g. separation of conformations, isotopes, double bond positions, stereoisomers, isotopologues, isotopomers, etc.) which could be markers for diseases. SLIM also enables IMS separations with high resolution, high throughput, high ion utilization efficiency. In this work, we will present SLIM technology and its game-changing ability to perform analytical separations with unprecedented utility and precision.
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AU  - Garimella, Sandilya
AU  - Li, Ailin
AU  - Harrilal, Chris
AU  - Ibrahim, Yehia M.
AU  - Smith, Richard  D.
DA  - 2020
DO  - 10.6083/w3763757r
DO  - DOI
ID  - 8288
KW  - Alzheimer Disease
KW  - Dementia
KW  - Amyloid beta-Peptides
KW  - structures for lossless ion manipulations
KW  - soft-landing of biomolecules
KW  - analytical technologies
L1  - https://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf
L2  - https://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf
L4  - https://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf
N2  - Advancements in ion mobility technology, particularly Structures for Lossless Ion Manipulations (SLIM), have enabled the detailed characterization of heterogeneity of biomolecular structures in a sample. SLIM enables the resolution of subtle variations of molecular structures (e.g. separation of conformations, isotopes, double bond positions, stereoisomers, isotopologues, isotopomers, etc.) which could be markers for diseases. SLIM also enables IMS separations with high resolution, high throughput, high ion utilization efficiency. In this work, we will present SLIM technology and its game-changing ability to perform analytical separations with unprecedented utility and precision.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Mass and structural selective ion soft_landing for separation, collection and characterization of amyloid-beta peptide structures and their role in Alzheimer disease
TI  - Mass and structural selective ion soft_landing for separation, collection and characterization of amyloid-beta peptide structures and their role in Alzheimer disease
UR  - https://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf
Y1  - 2020
ER  -