000008288 001__ 8288 000008288 005__ 20240411145617.0 000008288 0247_ $$2DOI$$a10.6083/w3763757r 000008288 037__ $$aIR 000008288 041__ $$aeng 000008288 245__ $$aMass and structural selective ion soft_landing for separation, collection and characterization of amyloid-beta peptide structures and their role in Alzheimer disease 000008288 260__ $$bOregon Health and Science University 000008288 269__ $$a2020 000008288 336__ $$aAbstract 000008288 520__ $$aAdvancements in ion mobility technology, particularly Structures for Lossless Ion Manipulations (SLIM), have enabled the detailed characterization of heterogeneity of biomolecular structures in a sample. SLIM enables the resolution of subtle variations of molecular structures (e.g. separation of conformations, isotopes, double bond positions, stereoisomers, isotopologues, isotopomers, etc.) which could be markers for diseases. SLIM also enables IMS separations with high resolution, high throughput, high ion utilization efficiency. In this work, we will present SLIM technology and its game-changing ability to perform analytical separations with unprecedented utility and precision. 000008288 540__ $$fCC BY 000008288 542__ $$fIn copyright - joint owners 000008288 650__ $$aAlzheimer Disease$$014513 000008288 650__ $$aDementia$$017461 000008288 650__ $$aAmyloid beta-Peptides$$028982 000008288 6531_ $$astructures for lossless ion manipulations 000008288 6531_ $$asoft-landing of biomolecules 000008288 6531_ $$aanalytical technologies 000008288 692__ $$aPNNL Biological Sciences Division$$041376 000008288 7001_ $$aGarimella, Sandilya$$uPacific Northwest National Laboratory$$041356 000008288 7001_ $$aLi, Ailin$$uPacific Northwest National Laboratory$$041356 000008288 7001_ $$aHarrilal, Chris$$uPacific Northwest National Laboratory$$041356 000008288 7001_ $$aIbrahim, Yehia M.$$uPacific Northwest National Laboratory$$041356 000008288 7001_ $$aSmith, Richard D.$$uPacific Northwest National Laboratory$$041356 000008288 711__ $$aResearch Week$$uOregon Health and Science University$$d2020 000008288 8564_ $$9b454ca36-a837-4f9f-8cff-30f948f7f6b0$$s48596$$uhttps://digitalcollections.ohsu.edu/record/8288/files/Sandilya-Garimella.pdf 000008288 905__ $$a/rest/prod/w3/76/37/57/w3763757r 000008288 980__ $$aResearch Week