@article{IR, recid = {8302}, author = {Nakayasu, Ernesto and Zamith-Miranda, D. and Heyman, H.M. and Burnet, M.C. and Couvillion, S.P. and Zheng, X. and Munoz, N. and Kyle, J.E. and Zink, E.M. and Weitz, K.K. and Bloodsworth, K.J. and Clair, G. and Zucker, J.D. and Teuton, J.R. and Payne, S.H. and Kim, Y.M. and Gil, M. Reyes and Baker, E.S. and Bredeweg, E.L. and Nosanchuk, J.D.}, title = {Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum}, publisher = {Oregon Health and Science University}, address = {2020}, number = {IR}, abstract = {Lipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.}, url = {http://digitalcollections.ohsu.edu/record/8302}, doi = {https://doi.org/10.6083/vh53ww31p}, }