TY  - GEN
N2  - Lipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.
DO  - 10.6083/vh53ww31p
DO  - DOI
AB  - Lipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
AD  - Pacific Northwest National Laboratory
T1  - Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum
DA  - 2020
AU  - Nakayasu, Ernesto
AU  - Zamith-Miranda, D.
AU  - Heyman, H.M.
AU  - Burnet, M.C.
AU  - Couvillion, S.P.
AU  - Zheng, X.
AU  - Munoz, N.
AU  - Kyle, J.E.
AU  - Zink, E.M.
AU  - Weitz, K.K.
AU  - Bloodsworth, K.J.
AU  - Clair, G.
AU  - Zucker, J.D.
AU  - Teuton, J.R.
AU  - Payne, S.H.
AU  - Kim, Y.M.
AU  - Gil, M. Reyes
AU  - Baker, E.S.
AU  - Bredeweg, E.L.
AU  - Nosanchuk, J.D.
L1  - https://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8302
L4  - https://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
KW  - Lipids
KW  - Lipid Bilayers
KW  - Multiomics
KW  - Virulence Factors
KW  - lipid metabolic pathways
KW  - lipid metabolic map
KW  - drug target
KW  - fungal infection
KW  - histoplasma capsulatum
KW  - fungal pathogenesis
TI  - Discovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
LK  - https://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
UR  - https://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
ER  -