000008302 001__ 8302
000008302 005__ 20240403151441.0
000008302 0247_ $$2DOI$$a10.6083/vh53ww31p
000008302 037__ $$aIR
000008302 041__ $$aeng
000008302 245__ $$aDiscovering drug targets and virulence factors by mapping the lipid metabolism of the pathogenic fungus histoplasma capsulatum
000008302 260__ $$bOregon Health and Science University
000008302 269__ $$a2020
000008302 336__ $$aAbstract
000008302 520__ $$aLipids are major components of biological membrane, energy storage molecules and cell signaling transducers. Therefore, not surprisingly, lipids play major function in host-pathogen interactions and are frequently targeted for drug development. Seeking to better understand the function of lipids in fungal pathogenesis and identify potential drug targets, we performed a comprehensive analysis of the Histoplasma capsulatum lipid metabolic pathway by integrating proteomic and lipidomic analyses. This analysis resulted in mapping of 5 major lipid metabolic pathways, 19 lipid subclasses and 371 individual lipid species.
000008302 540__ $$fCC BY
000008302 542__ $$fIn copyright - joint owners
000008302 650__ $$aLipids$$021539
000008302 650__ $$aLipid Bilayers$$021535
000008302 650__ $$aMultiomics$$014089
000008302 650__ $$aVirulence Factors$$034836
000008302 6531_ $$alipid metabolic pathways
000008302 6531_ $$alipid metabolic map
000008302 6531_ $$adrug target
000008302 6531_ $$afungal infection
000008302 6531_ $$ahistoplasma capsulatum
000008302 6531_ $$afungal pathogenesis
000008302 692__ $$aPNNL Biological Sciences Division$$041376
000008302 7001_ $$aNakayasu, Ernesto$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aZamith-Miranda, D.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aHeyman, H.M.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aBurnet, M.C.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aCouvillion, S.P.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aZheng, X.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aMunoz, N.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aKyle, J.E.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aZink, E.M.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aWeitz, K.K.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aBloodsworth, K.J.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aClair, G.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aZucker, J.D.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aTeuton, J.R.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aPayne, S.H.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aKim, Y.M.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aGil, M. Reyes$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aBaker, E.S.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aBredeweg, E.L.$$uPacific Northwest National Laboratory$$041356
000008302 7001_ $$aNosanchuk, J.D.$$uPacific Northwest National Laboratory$$041356
000008302 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008302 8564_ $$9695f914f-c865-425a-98dd-a7665cbf7c8d$$s47949$$uhttps://digitalcollections.ohsu.edu/record/8302/files/Ernesto-Nakayasu.pdf
000008302 905__ $$a/rest/prod/vh/53/ww/31/vh53ww31p
000008302 980__ $$aResearch Week