TY  - GEN
N2  - Alzheimer's disease (AD) is a neurological disorder that affects 44 million people worldwide and is the leading cause of dementia. It is characterized by memory loss, challenges with executive function, and difficulties learning and storing new information, among many other symptoms. Age is the most significant risk factor for AD, interacting with several genetic and environmental risk factors to contribute to disease manifestation. In addition to AD, age-related cognitive decline (ACD) and mild cognitive impairments (MCI) are of increasing concern with the increased longevity. There might be protective factors that can help mitigate the development of ACD, MCI, and AD. In this pilot study, we started to explore the effects of exercise as possible protective factor in human apoE mice. Voluntary wheel running, even in mild bouts, can improve cognition, memory, and executive function.
DO  - 10.6083/ht24wk041
DO  - DOI
AB  - Alzheimer's disease (AD) is a neurological disorder that affects 44 million people worldwide and is the leading cause of dementia. It is characterized by memory loss, challenges with executive function, and difficulties learning and storing new information, among many other symptoms. Age is the most significant risk factor for AD, interacting with several genetic and environmental risk factors to contribute to disease manifestation. In addition to AD, age-related cognitive decline (ACD) and mild cognitive impairments (MCI) are of increasing concern with the increased longevity. There might be protective factors that can help mitigate the development of ACD, MCI, and AD. In this pilot study, we started to explore the effects of exercise as possible protective factor in human apoE mice. Voluntary wheel running, even in mild bouts, can improve cognition, memory, and executive function.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Effects of voluntary exercise on behavioral and cognitive performance in mice; a pilot study
DA  - 2020
AU  - Perez, Ruby
AU  - Raber, Jacob
L1  - https://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8305
L4  - https://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
KW  - Exercise
KW  - Cognitive Dysfunction
KW  - Aging
KW  - Executive Function
KW  - Neurocognitive Disorders
KW  - Dementia
KW  - Alzheimer Disease
KW  - Rodentia
KW  - Mice
KW  - Memory
KW  - Learning
KW  - Cognition
KW  - Protective Factors
KW  - running wheel
KW  - neurological disorders
KW  - age related cognitive decline
KW  - mild cognitive impairments
KW  - physical activity
TI  - Effects of voluntary exercise on behavioral and cognitive performance in mice; a pilot study
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
LK  - https://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
UR  - https://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
ER  -