000008305 001__ 8305
000008305 005__ 20240405114739.0
000008305 0247_ $$2DOI$$a10.6083/ht24wk041
000008305 037__ $$aIR
000008305 041__ $$aeng
000008305 245__ $$aEffects of voluntary exercise on behavioral and cognitive performance in mice; a pilot study
000008305 260__ $$bOregon Health and Science University
000008305 269__ $$a2020
000008305 336__ $$aAbstract
000008305 520__ $$aAlzheimer's disease (AD) is a neurological disorder that affects 44 million people worldwide and is the leading cause of dementia. It is characterized by memory loss, challenges with executive function, and difficulties learning and storing new information, among many other symptoms. Age is the most significant risk factor for AD, interacting with several genetic and environmental risk factors to contribute to disease manifestation. In addition to AD, age-related cognitive decline (ACD) and mild cognitive impairments (MCI) are of increasing concern with the increased longevity. There might be protective factors that can help mitigate the development of ACD, MCI, and AD. In this pilot study, we started to explore the effects of exercise as possible protective factor in human apoE mice. Voluntary wheel running, even in mild bouts, can improve cognition, memory, and executive function.
000008305 536__ $$oNational Institute of Health$$cRF1 AG059088
000008305 540__ $$fCC BY
000008305 542__ $$fIn copyright - joint owners
000008305 650__ $$aExercise$$028419
000008305 650__ $$aCognitive Dysfunction$$039814
000008305 650__ $$aAging$$014358
000008305 650__ $$aExecutive Function$$038584
000008305 650__ $$aNeurocognitive Disorders$$032028
000008305 650__ $$aDementia$$017461
000008305 650__ $$aAlzheimer Disease$$014513
000008305 650__ $$aRodentia$$025590
000008305 650__ $$aMice$$036842
000008305 650__ $$aMemory$$022012
000008305 650__ $$aLearning$$021358
000008305 650__ $$aCognition$$016868
000008305 650__ $$aProtective Factors$$040725
000008305 6531_ $$arunning wheel
000008305 6531_ $$aneurological disorders
000008305 6531_ $$aage related cognitive decline
000008305 6531_ $$amild cognitive impairments
000008305 6531_ $$aphysical activity
000008305 691__ $$aSchool of Medicine$$041369
000008305 692__ $$aDepartment of Behavioral Neuroscience$$041394
000008305 7001_ $$aPerez, Ruby$$uOregon Health and Science University$$041354
000008305 7001_ $$aRaber, Jacob$$uOregon Health and Science University$$041354
000008305 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008305 8564_ $$9c33c9a56-1d8b-4b8d-a91d-03c18d4b24a2$$s47599$$uhttps://digitalcollections.ohsu.edu/record/8305/files/Ruby-Perez.pdf
000008305 905__ $$a/rest/prod/ht/24/wk/04/ht24wk041
000008305 980__ $$aResearch Week