TY  - GEN
N2  - Caenorhabditis elegans, a natural bacterivore, has proven to be a fruitful model organism for studying host-pathogen interactions, feeding behaviors, and learning. Previous studies have shown that the opportunistic human pathogen Enterococcus faecalis is a C. elegans pathogen, able to form a persistent, lethal infection in the intestine following ingestion. In addition to mounting a molecular immune response upon infection, C. elegans has developed avoidance strategies to escape harmful bacteria, homologous to danger avoidance seen in nearly all animals. Here, we describe both the molecular immune response and, for the first time, the behavioral response of C. elegans to E. faecalis. Immune signaling pathways come online quickly upon ingestion of E. faecalis. In addition, a fast form of aversive learning takes place along multiple sensory modalities in order to allow the animal to escape and avoid lethal patches of bacteria. Using the powerful genetic toolset available in C. elegans,?along with simple behavioral analyses, we have been able to begin elucidating the neuronal and molecular pathways governing this aversive learning.
DO  - 10.6083/sq87bv28m
DO  - DOI
AB  - Caenorhabditis elegans, a natural bacterivore, has proven to be a fruitful model organism for studying host-pathogen interactions, feeding behaviors, and learning. Previous studies have shown that the opportunistic human pathogen Enterococcus faecalis is a C. elegans pathogen, able to form a persistent, lethal infection in the intestine following ingestion. In addition to mounting a molecular immune response upon infection, C. elegans has developed avoidance strategies to escape harmful bacteria, homologous to danger avoidance seen in nearly all animals. Here, we describe both the molecular immune response and, for the first time, the behavioral response of C. elegans to E. faecalis. Immune signaling pathways come online quickly upon ingestion of E. faecalis. In addition, a fast form of aversive learning takes place along multiple sensory modalities in order to allow the animal to escape and avoid lethal patches of bacteria. Using the powerful genetic toolset available in C. elegans,?along with simple behavioral analyses, we have been able to begin elucidating the neuronal and molecular pathways governing this aversive learning.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Aversive learning in C. elegans upon E. faecalis infection
DA  - 2020
AU  - Filipowicz, Adam
AU  - Aballay, Alejandro
L1  - https://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8306
L4  - https://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
KW  - Immunity
KW  - Enterococcus faecalis
KW  - Avoidance Learning
KW  - Caenorhabditis elegans
KW  - Host-Pathogen Interactions
KW  - avoidance behavior
KW  - aversive learning
KW  - immune response
TI  - Aversive learning in C. elegans upon E. faecalis infection
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
LK  - https://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
UR  - https://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
ER  -