000008306 001__ 8306
000008306 005__ 20240328075956.0
000008306 0247_ $$2DOI$$a10.6083/sq87bv28m
000008306 037__ $$aIR
000008306 041__ $$aeng
000008306 245__ $$aAversive learning in C. elegans upon E. faecalis infection
000008306 260__ $$bOregon Health and Science University
000008306 269__ $$a2020
000008306 336__ $$aAbstract
000008306 520__ $$aCaenorhabditis elegans, a natural bacterivore, has proven to be a fruitful model organism for studying host-pathogen interactions, feeding behaviors, and learning. Previous studies have shown that the opportunistic human pathogen Enterococcus faecalis is a C. elegans pathogen, able to form a persistent, lethal infection in the intestine following ingestion. In addition to mounting a molecular immune response upon infection, C. elegans has developed avoidance strategies to escape harmful bacteria, homologous to danger avoidance seen in nearly all animals. Here, we describe both the molecular immune response and, for the first time, the behavioral response of C. elegans to E. faecalis. Immune signaling pathways come online quickly upon ingestion of E. faecalis. In addition, a fast form of aversive learning takes place along multiple sensory modalities in order to allow the animal to escape and avoid lethal patches of bacteria. Using the powerful genetic toolset available in C. elegans,?along with simple behavioral analyses, we have been able to begin elucidating the neuronal and molecular pathways governing this aversive learning.
000008306 540__ $$fCC BY
000008306 542__ $$fIn copyright - joint owners
000008306 650__ $$aImmunity$$020668
000008306 650__ $$aEnterococcus faecalis$$026448
000008306 650__ $$aAvoidance Learning$$015269
000008306 650__ $$aCaenorhabditis elegans$$029747
000008306 650__ $$aHost-Pathogen Interactions$$038099
000008306 6531_ $$aavoidance behavior
000008306 6531_ $$aaversive learning
000008306 6531_ $$aimmune response
000008306 691__ $$aSchool of Medicine$$041369
000008306 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008306 7001_ $$aFilipowicz, Adam$$uOregon Health and Science University$$041354
000008306 7001_ $$aAballay, Alejandro$$uOregon Health and Science University$$041354
000008306 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008306 8564_ $$9e6075128-6e4a-42e8-a4a6-21a3c5c925ac$$s41421$$uhttps://digitalcollections.ohsu.edu/record/8306/files/Adam-Filipowicz.pdf
000008306 905__ $$a/rest/prod/sq/87/bv/28/sq87bv28m
000008306 980__ $$aResearch Week