TY  - GEN
AB  - Globally, attention-deficit/hyperactivity disorder (ADHD), affects children, adolescents and adults, and can cause reduced academic achievement, occupational struggles, and social disability. Past research has attempted to explain the contributions of genetic and environmental factors in the functional connectivity of the human brain using twin's studies. The variation in genetic risk factors for ADHD explain a minimal proportion of observed cases, which suggests how genes are expressed and appear to affect the likelihood of diagnosis. While differences in neural functional connectivity have been observed on ADHD and typically developing children, the extent which these epigenetic factors contribute to differential neural behavior has not been investigated. To investigate epigenetic factors, one needs a cohort of twins that has discordant ADHD diagnoses, high quality resting-state functional magnetic resonance imaging (MRI) data, and epigenetic markers. We found that methylation at specific DNA sites was significantly correlated with surface area of the visual, dorsal attention, and salience networks in the cortex. This suggest that these three networks are expressing certain genes deferentially due to environmental factors, which affects the topology of the brain and may account for diagnosis outcome.
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AU  - Estrada-Sanchez, Favio
AU  - Hermosillo, Robert
AU  - Nigg, Joel
AU  - Mooney, Michael
AU  - Nardos, Binyam
AU  - Earl, Eric
AU  - Fair, Damien
DA  - 2020
DO  - 10.6083/b5644s23m
DO  - DOI
ID  - 8307
KW  - Mental Disorders
KW  - Mental Health
KW  - Neurodevelopmental Disorders
KW  - Gene Expression
KW  - Attention Deficit Disorder with Hyperactivity
KW  - neural networks
KW  - epigenetics
L1  - https://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
L2  - https://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
L4  - https://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
N2  - Globally, attention-deficit/hyperactivity disorder (ADHD), affects children, adolescents and adults, and can cause reduced academic achievement, occupational struggles, and social disability. Past research has attempted to explain the contributions of genetic and environmental factors in the functional connectivity of the human brain using twin's studies. The variation in genetic risk factors for ADHD explain a minimal proportion of observed cases, which suggests how genes are expressed and appear to affect the likelihood of diagnosis. While differences in neural functional connectivity have been observed on ADHD and typically developing children, the extent which these epigenetic factors contribute to differential neural behavior has not been investigated. To investigate epigenetic factors, one needs a cohort of twins that has discordant ADHD diagnoses, high quality resting-state functional magnetic resonance imaging (MRI) data, and epigenetic markers. We found that methylation at specific DNA sites was significantly correlated with surface area of the visual, dorsal attention, and salience networks in the cortex. This suggest that these three networks are expressing certain genes deferentially due to environmental factors, which affects the topology of the brain and may account for diagnosis outcome.
PB  - Oregon Health and Science University
PY  - 2020
T1  - DNA methylation correlates with network surface area in discordant ADHD twins
TI  - DNA methylation correlates with network surface area in discordant ADHD twins
UR  - https://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
Y1  - 2020
ER  -