000008307 001__ 8307
000008307 005__ 20240403154553.0
000008307 0247_ $$2DOI$$a10.6083/b5644s23m
000008307 037__ $$aIR
000008307 041__ $$aeng
000008307 245__ $$aDNA methylation correlates with network surface area in discordant ADHD twins
000008307 260__ $$bOregon Health and Science University
000008307 269__ $$a2020
000008307 336__ $$aAbstract
000008307 520__ $$aGlobally, attention-deficit/hyperactivity disorder (ADHD), affects children, adolescents and adults, and can cause reduced academic achievement, occupational struggles, and social disability. Past research has attempted to explain the contributions of genetic and environmental factors in the functional connectivity of the human brain using twin's studies. The variation in genetic risk factors for ADHD explain a minimal proportion of observed cases, which suggests how genes are expressed and appear to affect the likelihood of diagnosis. While differences in neural functional connectivity have been observed on ADHD and typically developing children, the extent which these epigenetic factors contribute to differential neural behavior has not been investigated. To investigate epigenetic factors, one needs a cohort of twins that has discordant ADHD diagnoses, high quality resting-state functional magnetic resonance imaging (MRI) data, and epigenetic markers. We found that methylation at specific DNA sites was significantly correlated with surface area of the visual, dorsal attention, and salience networks in the cortex. This suggest that these three networks are expressing certain genes deferentially due to environmental factors, which affects the topology of the brain and may account for diagnosis outcome.
000008307 540__ $$fCC BY
000008307 542__ $$fIn copyright - joint owners
000008307 650__ $$aMental Disorders$$015415
000008307 650__ $$aMental Health$$022046
000008307 650__ $$aNeurodevelopmental Disorders$$040742
000008307 650__ $$aGene Expression$$028717
000008307 650__ $$aAttention Deficit Disorder with Hyperactivity$$015204
000008307 6531_ $$aneural networks
000008307 6531_ $$aepigenetics
000008307 7001_ $$aEstrada-Sanchez, Favio$$uPortland State University$$041357
000008307 7001_ $$aHermosillo, Robert$$uPortland State University$$041357
000008307 7001_ $$aNigg, Joel$$uPortland State University$$041357
000008307 7001_ $$aMooney, Michael$$uPortland State University$$041357
000008307 7001_ $$aNardos, Binyam$$uPortland State University$$041357
000008307 7001_ $$aEarl, Eric$$uPortland State University$$041357
000008307 7001_ $$aFair, Damien$$uPortland State University$$041357
000008307 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008307 8564_ $$9cb3c36ad-a828-42aa-ad99-8c7ee7138fe0$$s44253$$uhttps://digitalcollections.ohsu.edu/record/8307/files/Favio-Estrada.pdf
000008307 905__ $$a/rest/prod/b5/64/4s/23/b5644s23m
000008307 980__ $$aResearch Week