TY  - GEN
AB  - Women are impacted twice as likely as men by urgency urinary incontinence (UUI) with nearly one-third of women suffering from UUI in their lifetime. The etiology of UUI is complex, but evidence suggests that shifts in the normal urinary microbiome may play a role in UUI. We aim to understand whether women with UUI have different urinary bacterial loads compared to women without UUI and whether this is correlated with severity of UUI symptoms. Our prospective cohort study compares urinary microbiome in women with and without UUI. This study provides evidence that women with UUI have significantly higher urinary bacterial load, but the higher bacterial load was associated with less severe symptoms. Larger bacterial load in women with UUI symptoms may represent a mix of both pathogenic and commensal bacteria and that symptom severity is dependent on proportion between these two types of bacteria rather than the overall abundance.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Leung, Eric
AU  - Jallow, Fatoumata
AU  - Schleisman, Matthew
AU  - Rodriguez, Manny
AU  - Gregory, Tom
AU  - Nardos, Rahel
DA  - 2020
DO  - 10.6083/nz806029d
DO  - DOI
ID  - 8321
KW  - Bacterial Load
KW  - Urinary Incontinence, Urge
KW  - Urinary Incontinence
KW  - urinary microbiome
KW  - quantitative microbiome profiling
L1  - https://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
L2  - https://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
L4  - https://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
LK  - https://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
N2  - Women are impacted twice as likely as men by urgency urinary incontinence (UUI) with nearly one-third of women suffering from UUI in their lifetime. The etiology of UUI is complex, but evidence suggests that shifts in the normal urinary microbiome may play a role in UUI. We aim to understand whether women with UUI have different urinary bacterial loads compared to women without UUI and whether this is correlated with severity of UUI symptoms. Our prospective cohort study compares urinary microbiome in women with and without UUI. This study provides evidence that women with UUI have significantly higher urinary bacterial load, but the higher bacterial load was associated with less severe symptoms. Larger bacterial load in women with UUI symptoms may represent a mix of both pathogenic and commensal bacteria and that symptom severity is dependent on proportion between these two types of bacteria rather than the overall abundance.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Associations between urinary bacterial load and UUI symptoms
TI  - Associations between urinary bacterial load and UUI symptoms
UR  - https://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
Y1  - 2020
ER  -