000008321 001__ 8321
000008321 005__ 20240125142328.0
000008321 0247_ $$2DOI$$a10.6083/nz806029d
000008321 037__ $$aIR
000008321 245__ $$aAssociations between urinary bacterial load and UUI symptoms
000008321 260__ $$bOregon Health and Science University
000008321 269__ $$a2020
000008321 336__ $$aAbstract
000008321 520__ $$aWomen are impacted twice as likely as men by urgency urinary incontinence (UUI) with nearly one-third of women suffering from UUI in their lifetime. The etiology of UUI is complex, but evidence suggests that shifts in the normal urinary microbiome may play a role in UUI. We aim to understand whether women with UUI have different urinary bacterial loads compared to women without UUI and whether this is correlated with severity of UUI symptoms. Our prospective cohort study compares urinary microbiome in women with and without UUI. This study provides evidence that women with UUI have significantly higher urinary bacterial load, but the higher bacterial load was associated with less severe symptoms. Larger bacterial load in women with UUI symptoms may represent a mix of both pathogenic and commensal bacteria and that symptom severity is dependent on proportion between these two types of bacteria rather than the overall abundance.
000008321 540__ $$fCC BY
000008321 542__ $$fIn copyright - joint owners
000008321 650__ $$aBacterial Load$$039214
000008321 650__ $$aUrinary Incontinence, Urge$$037303
000008321 650__ $$aUrinary Incontinence$$027635
000008321 6531_ $$aurinary microbiome
000008321 6531_ $$aquantitative microbiome profiling
000008321 691__ $$aSchool of Medicine$$041369
000008321 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000008321 7001_ $$aLeung, Eric$$uOregon Health and Science University$$041354
000008321 7001_ $$aJallow, Fatoumata$$uOregon Health and Science University$$041354
000008321 7001_ $$aSchleisman, Matthew$$uOregon Health and Science University$$041354
000008321 7001_ $$aRodriguez, Manny$$uOregon Health and Science University$$041354
000008321 7001_ $$aGregory, Tom$$uOregon Health and Science University$$041354
000008321 7001_ $$aNardos, Rahel$$uOregon Health and Science University$$041354
000008321 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008321 8564_ $$98d1e616c-ae61-49b3-afb5-f6bcbe4315d6$$s46051$$uhttps://digitalcollections.ohsu.edu/record/8321/files/ResearchWeek.2020.Leung.Eric.pdf
000008321 905__ $$a/rest/prod/nz/80/60/29/nz806029d
000008321 980__ $$aResearch Week