TY  - GEN
AB  - Myelin ensheaths axons and increases their conduction velocities. In the central nervous system (CNS) myelin is produced by oligodendrocytes (OLs) that differentiate from oligodendrocyte progenitor cells (OPCs) throughout life. Demyelination and neurodegeneration are observed in many forms of white matter injury and disease, one of which is multiple sclerosis (MS). OPCs accumulate and fail to differentiate into OLs within MS lesions, inside which there is an increase in the levels of extracellular hyaluronic acid (HA), a linear glycosaminoglycan polymer that can be mega-Daltons in size. HA fragments produced by the enzymatic digestion of high molecular weight HA have been shown to inhibit OPC differentiation and myelin formation. There is debate as to which specific hyaluronidase generates these smaller, inhibitory HA fragments. These studies could lead to the identification of CEMIP as a new therapeutic target to promote functional remyelination in a variety of demyelinated lesions, such as preterm white matter injury and MS.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Peters, Alec
AU  - Banine, Fatima
AU  - Su, Weiping
AU  - Pham, Peter
AU  - Sherman, Lawrence
DA  - 2020
DO  - 10.6083/pr76f411b
DO  - DOI
ID  - 8324
KW  - Hyaluronic Acid
KW  - Extracellular Matrix
KW  - Multiple Sclerosis
KW  - Central Nervous System
KW  - CEMIP
KW  - myelination
KW  - oligodendocytes
L1  - https://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
L2  - https://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
L4  - https://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
LK  - https://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
N2  - Myelin ensheaths axons and increases their conduction velocities. In the central nervous system (CNS) myelin is produced by oligodendrocytes (OLs) that differentiate from oligodendrocyte progenitor cells (OPCs) throughout life. Demyelination and neurodegeneration are observed in many forms of white matter injury and disease, one of which is multiple sclerosis (MS). OPCs accumulate and fail to differentiate into OLs within MS lesions, inside which there is an increase in the levels of extracellular hyaluronic acid (HA), a linear glycosaminoglycan polymer that can be mega-Daltons in size. HA fragments produced by the enzymatic digestion of high molecular weight HA have been shown to inhibit OPC differentiation and myelin formation. There is debate as to which specific hyaluronidase generates these smaller, inhibitory HA fragments. These studies could lead to the identification of CEMIP as a new therapeutic target to promote functional remyelination in a variety of demyelinated lesions, such as preterm white matter injury and MS.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Investigating cell migration inducing and hyaluronan binding protein in central nervous system development and disease
TI  - Investigating cell migration inducing and hyaluronan binding protein in central nervous system development and disease
UR  - https://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
Y1  - 2020
ER  -