000008324 001__ 8324
000008324 005__ 20240410113200.0
000008324 0247_ $$2DOI$$a10.6083/pr76f411b
000008324 037__ $$aIR
000008324 245__ $$aInvestigating cell migration inducing and hyaluronan binding protein in central nervous system development and disease
000008324 260__ $$bOregon Health and Science University
000008324 269__ $$a2020
000008324 336__ $$aAbstract
000008324 520__ $$aMyelin ensheaths axons and increases their conduction velocities. In the central nervous system (CNS) myelin is produced by oligodendrocytes (OLs) that differentiate from oligodendrocyte progenitor cells (OPCs) throughout life. Demyelination and neurodegeneration are observed in many forms of white matter injury and disease, one of which is multiple sclerosis (MS). OPCs accumulate and fail to differentiate into OLs within MS lesions, inside which there is an increase in the levels of extracellular hyaluronic acid (HA), a linear glycosaminoglycan polymer that can be mega-Daltons in size. HA fragments produced by the enzymatic digestion of high molecular weight HA have been shown to inhibit OPC differentiation and myelin formation. There is debate as to which specific hyaluronidase generates these smaller, inhibitory HA fragments. These studies could lead to the identification of CEMIP as a new therapeutic target to promote functional remyelination in a variety of demyelinated lesions, such as preterm white matter injury and MS.
000008324 540__ $$fCC BY
000008324 542__ $$fIn copyright - joint owners
000008324 650__ $$aHyaluronic Acid$$020392
000008324 650__ $$aExtracellular Matrix$$018796
000008324 650__ $$aMultiple Sclerosis$$022506
000008324 650__ $$aCentral Nervous System$$016312
000008324 6531_ $$aCEMIP
000008324 6531_ $$amyelination
000008324 6531_ $$aoligodendocytes
000008324 691__ $$aSchool of Medicine$$041369
000008324 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000008324 7001_ $$aPeters, Alec$$uOregon Health and Science University$$041354
000008324 7001_ $$aBanine, Fatima$$uOregon Health and Science University$$041354
000008324 7001_ $$aSu, Weiping$$uOregon Health and Science University$$041354
000008324 7001_ $$aPham, Peter$$uOregon Health and Science University$$041354
000008324 7001_ $$aSherman, Lawrence$$uOregon Health and Science University$$041354
000008324 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008324 8564_ $$9219adb70-8644-45df-9827-731d1a0e5870$$s43229$$uhttps://digitalcollections.ohsu.edu/record/8324/files/ResearchWeek.2020.Peters.Alec.pdf
000008324 905__ $$a/rest/prod/pr/76/f4/11/pr76f411b
000008324 980__ $$aResearch Week