TY  - GEN
N2  - Given its central role in low-density lipoprotein (LDL) metabolism, there is interest in exploring proprotein convertase subtisilin/kexin type 9 (PCSK9) as a potential circulating biomarker of atherosclerotic cardiovascular disease (ASCVD) risk. Computed tomography for coronary artery calcium (CAC) scoring provides an accurate assessment of subclinical coronary atherosclerotic plaque burden and can be used to refine cardiovascular risk estimates in individuals without symptoms of ASCVD. In this study, we assessed the correlation of cross-sectional measurements of plasma PCSK9 concentration and CAC score in individuals free of clinical ASCVD.
DO  - 10.6083/5d86p096x
DO  - DOI
AB  - Given its central role in low-density lipoprotein (LDL) metabolism, there is interest in exploring proprotein convertase subtisilin/kexin type 9 (PCSK9) as a potential circulating biomarker of atherosclerotic cardiovascular disease (ASCVD) risk. Computed tomography for coronary artery calcium (CAC) scoring provides an accurate assessment of subclinical coronary atherosclerotic plaque burden and can be used to refine cardiovascular risk estimates in individuals without symptoms of ASCVD. In this study, we assessed the correlation of cross-sectional measurements of plasma PCSK9 concentration and CAC score in individuals free of clinical ASCVD.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Association between plasma PCSK9 levels and computed topographic coronary artery calcium
DA  - 2020
AU  - Mahmood, Tahir
AU  - Minnier, Jessica
AU  - Miles, Joshua
AU  - Warden, Bruce
AU  - Fazio, Sergio
AU  - Shapiro, Michael D.
L1  - https://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8326
L4  - https://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
KW  - Cardiovascular Diseases
KW  - Atherosclerosis
KW  - PCSK9 Inhibitors
KW  - coronary artery calcium
KW  - low-density lipoprotein metabolism
KW  - cardiology
KW  - ldl receptors
KW  - arteries
TI  - Association between plasma PCSK9 levels and computed topographic coronary artery calcium
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
LK  - https://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
UR  - https://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
ER  -