000008326 001__ 8326
000008326 005__ 20240125142328.0
000008326 0247_ $$2DOI$$a10.6083/5d86p096x
000008326 037__ $$aIR
000008326 245__ $$aAssociation between plasma PCSK9 levels and computed topographic coronary artery calcium
000008326 260__ $$bOregon Health and Science University
000008326 269__ $$a2020
000008326 336__ $$aAbstract
000008326 520__ $$aGiven its central role in low-density lipoprotein (LDL) metabolism, there is interest in exploring proprotein convertase subtisilin/kexin type 9 (PCSK9) as a potential circulating biomarker of atherosclerotic cardiovascular disease (ASCVD) risk. Computed tomography for coronary artery calcium (CAC) scoring provides an accurate assessment of subclinical coronary atherosclerotic plaque burden and can be used to refine cardiovascular risk estimates in individuals without symptoms of ASCVD. In this study, we assessed the correlation of cross-sectional measurements of plasma PCSK9 concentration and CAC score in individuals free of clinical ASCVD.
000008326 540__ $$fCC BY
000008326 542__ $$fIn copyright - joint owners
000008326 650__ $$aCardiovascular Diseases$$016152
000008326 650__ $$aAtherosclerosis$$036329
000008326 650__ $$aPCSK9 Inhibitors$$013802
000008326 6531_ $$acoronary artery calcium
000008326 6531_ $$alow-density lipoprotein metabolism
000008326 6531_ $$acardiology
000008326 6531_ $$aldl receptors
000008326 6531_ $$aarteries
000008326 692__ $$aOHSU Knight Cardiovascular Institute$$041489
000008326 7001_ $$aMahmood, Tahir$$uOregon Health and Science University$$041354
000008326 7001_ $$aMinnier, Jessica$$uOregon Health and Science University$$041354
000008326 7001_ $$aMiles, Joshua$$uOregon Health and Science University$$041354
000008326 7001_ $$aWarden, Bruce$$uOregon Health and Science University$$041354
000008326 7001_ $$aFazio, Sergio$$uOregon Health and Science University$$041354
000008326 7001_ $$aShapiro, Michael D.$$uOregon Health and Science University$$041354
000008326 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008326 8564_ $$944dfc1e1-c876-4091-a89b-a8f4a4dafe42$$s49606$$uhttps://digitalcollections.ohsu.edu/record/8326/files/ResearchWeek.2020.Mahmood.Tahir.pdf
000008326 905__ $$a/rest/prod/5d/86/p0/96/5d86p096x
000008326 980__ $$aResearch Week