@article{IR,
      recid = {8328},
      author = {Brandes, Mikah and Zweig, Jonathan A. and Tang, Anita and  Caruso, Maya and Wright, Kirsten M. and Soumyanath, Amala  and Quinn, Joseph F. and Gray, Nora E.},
      title = {Long-term Centella asiatica treatment improves cognition,  increases synaptic and antioxidant markers and reduces  plaque burden in β-amyloid overexpressing mice},
      publisher = {Oregon Health and Science University},
      address = {2020},
      number = {IR},
      abstract = {We have previously reported that short-term treatment with  the water extract of Centella asiatica (CAW) activates the  endogenous antioxidant response pathway and ameliorates  cognitive deficits without altering plaque burden in mouse  models of β-amyloid (Aβ). Here we investigate whether  prolonged CAW exposure in 5xFAD mice has similar effects on  cognitive function and Aβ pathology, in addition to markers  of antioxidant response and synaptic plasticity. We also  used primary neurons isolated from 5xFAD mice to explore  how the antioxidant response pathway contributes to these  effects.},
      url = {http://digitalcollections.ohsu.edu/record/8328},
      doi = {https://doi.org/10.6083/fj2362670},
}