TY  - GEN
N2  - We have previously reported that short-term treatment with the water extract of Centella asiatica (CAW) activates the endogenous antioxidant response pathway and ameliorates cognitive deficits without altering plaque burden in mouse models of β-amyloid (Aβ). Here we investigate whether prolonged CAW exposure in 5xFAD mice has similar effects on cognitive function and Aβ pathology, in addition to markers of antioxidant response and synaptic plasticity. We also used primary neurons isolated from 5xFAD mice to explore how the antioxidant response pathway contributes to these effects.
DO  - 10.6083/fj2362670
DO  - DOI
AB  - We have previously reported that short-term treatment with the water extract of Centella asiatica (CAW) activates the endogenous antioxidant response pathway and ameliorates cognitive deficits without altering plaque burden in mouse models of β-amyloid (Aβ). Here we investigate whether prolonged CAW exposure in 5xFAD mice has similar effects on cognitive function and Aβ pathology, in addition to markers of antioxidant response and synaptic plasticity. We also used primary neurons isolated from 5xFAD mice to explore how the antioxidant response pathway contributes to these effects.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Long-term Centella asiatica treatment improves cognition, increases synaptic and antioxidant markers and reduces plaque burden in β-amyloid overexpressing mice
DA  - 2020
AU  - Brandes, Mikah
AU  - Zweig, Jonathan A.
AU  - Tang, Anita
AU  - Caruso, Maya
AU  - Wright, Kirsten M.
AU  - Soumyanath, Amala
AU  - Quinn, Joseph F.
AU  - Gray, Nora E.
L1  - https://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8328
L4  - https://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
KW  - Neuronal Plasticity
KW  - Antioxidants
KW  - Amyloid beta-Peptides
KW  - Cognitive Dysfunction
KW  - nrf2
KW  - nfe2l2 protein
KW  - centella asiatica
KW  - synaptic plasticity
TI  - Long-term Centella asiatica treatment improves cognition, increases synaptic and antioxidant markers and reduces plaque burden in β-amyloid overexpressing mice
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
LK  - https://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
UR  - https://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
ER  -