000008328 001__ 8328
000008328 005__ 20240411122416.0
000008328 0247_ $$2DOI$$a10.6083/fj2362670
000008328 037__ $$aIR
000008328 245__ $$aLong-term Centella asiatica treatment improves cognition, increases synaptic and antioxidant markers and reduces plaque burden in β-amyloid overexpressing mice
000008328 260__ $$bOregon Health and Science University
000008328 269__ $$a2020
000008328 336__ $$aAbstract
000008328 520__ $$aWe have previously reported that short-term treatment with the water extract of Centella asiatica (CAW) activates the endogenous antioxidant response pathway and ameliorates cognitive deficits without altering plaque burden in mouse models of β-amyloid (Aβ). Here we investigate whether prolonged CAW exposure in 5xFAD mice has similar effects on cognitive function and Aβ pathology, in addition to markers of antioxidant response and synaptic plasticity. We also used primary neurons isolated from 5xFAD mice to explore how the antioxidant response pathway contributes to these effects.
000008328 540__ $$fCC BY
000008328 542__ $$fIn copyright - joint owners
000008328 650__ $$aNeuronal Plasticity$$022857
000008328 650__ $$aAntioxidants$$014915
000008328 650__ $$aAmyloid beta-Peptides$$028982
000008328 650__ $$aCognitive Dysfunction$$039814
000008328 6531_ $$anrf2
000008328 6531_ $$anfe2l2 protein
000008328 6531_ $$acentella asiatica
000008328 6531_ $$asynaptic plasticity
000008328 691__ $$aSchool of Medicine$$041369
000008328 692__ $$aDepartment of Neurology$$041431
000008328 7001_ $$aBrandes, Mikah$$uOregon Health and Science University$$041354
000008328 7001_ $$aZweig, Jonathan A.$$uOregon Health and Science University$$041354
000008328 7001_ $$aTang, Anita$$uOregon Health and Science University$$041354
000008328 7001_ $$aCaruso, Maya$$uOregon Health and Science University$$041354
000008328 7001_ $$aWright, Kirsten M.$$uOregon Health and Science University$$041354
000008328 7001_ $$aSoumyanath, Amala$$uOregon Health and Science University$$041354
000008328 7001_ $$aQuinn, Joseph F.$$uOregon Health and Science University$$041354
000008328 7001_ $$aGray, Nora E.$$uOregon Health and Science University$$041354
000008328 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008328 8564_ $$9ff23be4f-11a1-4a64-bbf7-bf9763186088$$s69878$$uhttps://digitalcollections.ohsu.edu/record/8328/files/ResearchWeek.2020.Brandes.Mikah.pdf
000008328 905__ $$a/rest/prod/fj/23/62/67/fj2362670
000008328 980__ $$aResearch Week