TY  - GEN
N2  - The clinical standard for small diameter vessel treatment, currently, is the use of autologous vessels. However, due to limited availability and pre-surgical complications, many patients are ineligible for this treatment. In addition, synthetic vascular grafts have been shown to exhibit limited long-term patency at diameters less than 6 mm, creating a large unmet clinical need. By biochemically modifying the surface of small diameter poly(vinyl alcohol) (PVA) grafts, anti-thrombotic properties can be achieved. Previously, thrombogenicity has been investigated through an ex vivo, non-human primate, shunt model. However, this model only characterizes platelet attachment over the length of the entire graft, losing the ability for dynamic physical properties of the thrombus along the graft to be understood. This work introduces a novel method to quantify thrombus formation along the cross-sectional area of biochemically-modified PVA grafts.
DO  - 10.6083/th83m0006
DO  - DOI
AB  - The clinical standard for small diameter vessel treatment, currently, is the use of autologous vessels. However, due to limited availability and pre-surgical complications, many patients are ineligible for this treatment. In addition, synthetic vascular grafts have been shown to exhibit limited long-term patency at diameters less than 6 mm, creating a large unmet clinical need. By biochemically modifying the surface of small diameter poly(vinyl alcohol) (PVA) grafts, anti-thrombotic properties can be achieved. Previously, thrombogenicity has been investigated through an ex vivo, non-human primate, shunt model. However, this model only characterizes platelet attachment over the length of the entire graft, losing the ability for dynamic physical properties of the thrombus along the graft to be understood. This work introduces a novel method to quantify thrombus formation along the cross-sectional area of biochemically-modified PVA grafts.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - A novel method for the quantification of platelet adhesion on biochemically-modified poly(vinyl alcohol) vascular grafts
DA  - 2020
AU  - Fallon, Meghan
AU  - Yao, Yuan
AU  - Yim, Evelyn K.F.
AU  - Hinds, Monica T.
AU  - Anderson, Deirdre
L1  - https://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8330
L4  - https://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
KW  - Thrombosis
KW  - Vascular Grafting
KW  - surface modification
KW  - platelet adhesion
KW  - micro-ct imaging
KW  - thrombogenicity
KW  - small diameter blood vessels
TI  - A novel method for the quantification of platelet adhesion on biochemically-modified poly(vinyl alcohol) vascular grafts
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
LK  - https://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
UR  - https://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
ER  -