000008330 001__ 8330
000008330 005__ 20240125142325.0
000008330 0247_ $$2DOI$$a10.6083/th83m0006
000008330 037__ $$aIR
000008330 245__ $$aA novel method for the quantification of platelet adhesion on biochemically-modified poly(vinyl alcohol) vascular grafts
000008330 260__ $$bOregon Health and Science University
000008330 269__ $$a2020
000008330 336__ $$aAbstract
000008330 520__ $$aThe clinical standard for small diameter vessel treatment, currently, is the use of autologous vessels. However, due to limited availability and pre-surgical complications, many patients are ineligible for this treatment. In addition, synthetic vascular grafts have been shown to exhibit limited long-term patency at diameters less than 6 mm, creating a large unmet clinical need. By biochemically modifying the surface of small diameter poly(vinyl alcohol) (PVA) grafts, anti-thrombotic properties can be achieved. Previously, thrombogenicity has been investigated through an ex vivo, non-human primate, shunt model. However, this model only characterizes platelet attachment over the length of the entire graft, losing the ability for dynamic physical properties of the thrombus along the graft to be understood. This work introduces a novel method to quantify thrombus formation along the cross-sectional area of biochemically-modified PVA grafts.
000008330 540__ $$fCC BY
000008330 542__ $$fIn copyright - joint owners
000008330 650__ $$aThrombosis
000008330 650__ $$aVascular Grafting$$039073
000008330 6531_ $$asurface modification
000008330 6531_ $$aplatelet adhesion
000008330 6531_ $$amicro-ct imaging
000008330 6531_ $$athrombogenicity
000008330 6531_ $$asmall diameter blood vessels
000008330 691__ $$aSchool of Medicine$$041369
000008330 692__ $$aDepartment of Biomedical Engineering$$041397
000008330 7001_ $$aFallon, Meghan$$uOregon Health and Science University$$041354
000008330 7001_ $$aYao, Yuan$$uOregon Health and Science University$$041354
000008330 7001_ $$aYim, Evelyn K.F.$$uOregon Health and Science University$$041354
000008330 7001_ $$aHinds, Monica T.$$uOregon Health and Science University$$041354
000008330 7001_ $$aAnderson, Deirdre$$uOregon Health and Science University$$041354
000008330 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008330 8564_ $$9d83f15ac-ec0c-444c-98ff-1ceb84f202e6$$s45538$$uhttps://digitalcollections.ohsu.edu/record/8330/files/ResearchWeek.2020.Fallon.Meghan.pdf
000008330 905__ $$a/rest/prod/th/83/m0/00/th83m0006
000008330 980__ $$aResearch Week