TY  - GEN
N2  - Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical research. However, studies using very old monkeys have been impeded by lack of access to animals of advanced age. As the average lifespan of a rhesus macaque is reported to be 25 years, acquiring animals of this age can be both time- and cost-prohibitive. Our laboratory, via a collaborative pooling of resources, has access to postmortem tissue from a cohort containing some of the oldest known macaques in the world, with three animals having lived more than 40 years. Due to this unique resource, we are able to examine whether specific normative or pathological brain aging processes occur in the macaque brain. Specifically, we are interested in whether the rhesus monkey naturally develops Alzheimer's disease (AD) phenotypes.
DO  - 10.6083/f4752h38h
DO  - DOI
AB  - Due to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical research. However, studies using very old monkeys have been impeded by lack of access to animals of advanced age. As the average lifespan of a rhesus macaque is reported to be 25 years, acquiring animals of this age can be both time- and cost-prohibitive. Our laboratory, via a collaborative pooling of resources, has access to postmortem tissue from a cohort containing some of the oldest known macaques in the world, with three animals having lived more than 40 years. Due to this unique resource, we are able to examine whether specific normative or pathological brain aging processes occur in the macaque brain. Specifically, we are interested in whether the rhesus monkey naturally develops Alzheimer's disease (AD) phenotypes.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - The aged rhesus macaque hippocampus exhibits previously undetected pathological tau
ED  - Mattison, Julie
ED  - Collaborator
DA  - 2020
AU  - Stonebarger, Gail
AU  - Brown, D.I.
AU  - Krajbich, V.K.
AU  - Woltjer, R.L.
AU  - Rosene, Doug L.
AU  - Urbanksi, H.F.
AU  - Kohama, Steve G.
L1  - https://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8331
L4  - https://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
KW  - Aging
KW  - Alzheimer's Disease
KW  - Cognition
KW  - Macaca mulatta
KW  - Immunohistochemistry
KW  - biosensors
KW  - nonhuman primate
KW  - tau
KW  - neurodegeneration
KW  - amyloid beta plaques
TI  - The aged rhesus macaque hippocampus exhibits previously undetected pathological tau
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
LK  - https://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
UR  - https://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
ER  -