000008331 001__ 8331
000008331 005__ 20240417095256.0
000008331 0247_ $$2DOI$$a10.6083/f4752h38h
000008331 037__ $$aIR
000008331 245__ $$aThe aged rhesus macaque hippocampus exhibits previously undetected pathological tau
000008331 260__ $$bOregon Health and Science University
000008331 269__ $$a2020
000008331 336__ $$aAbstract
000008331 520__ $$aDue to their genetic, behavioral, and physiological similarities to humans, rhesus macaques (Macacca mulatta) have long been used as a translational model in biomedical research. However, studies using very old monkeys have been impeded by lack of access to animals of advanced age. As the average lifespan of a rhesus macaque is reported to be 25 years, acquiring animals of this age can be both time- and cost-prohibitive. Our laboratory, via a collaborative pooling of resources, has access to postmortem tissue from a cohort containing some of the oldest known macaques in the world, with three animals having lived more than 40 years. Due to this unique resource, we are able to examine whether specific normative or pathological brain aging processes occur in the macaque brain. Specifically, we are interested in whether the rhesus monkey naturally develops Alzheimer's disease (AD) phenotypes.
000008331 540__ $$fCC BY
000008331 542__ $$fIn copyright - joint owners
000008331 650__ $$aAging$$014358
000008331 650__ $$aAlzheimer's Disease$$014513
000008331 650__ $$aCognition$$016868
000008331 650__ $$aMacaca mulatta$$021724
000008331 650__ $$aImmunohistochemistry$$020708
000008331 6531_ $$abiosensors
000008331 6531_ $$anonhuman primate
000008331 6531_ $$atau
000008331 6531_ $$aneurodegeneration
000008331 6531_ $$aamyloid beta plaques
000008331 691__ $$aSchool of Medicine$$041369
000008331 692__ $$aDepartment of Behavioral Neuroscience$$041394
000008331 7001_ $$aStonebarger, Gail$$uOregon Health and Science University$$041354
000008331 7001_ $$aBrown, D.I.$$uOregon Health and Science University$$041354
000008331 7001_ $$aKrajbich, V.K.$$uOregon Health and Science University$$041354
000008331 7001_ $$aWoltjer, R.L.$$uOregon Health and Science University$$041354
000008331 7001_ $$aRosene, Doug L.$$uOregon Health and Science University$$041354
000008331 7001_ $$aUrbanksi, H.F.$$uOregon Health and Science University$$041354
000008331 7001_ $$aKohama, Steve G.$$uOregon Health and Science University$$041354
000008331 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008331 7201_ $$aMattison, Julie$$uOregon Health and Science University$$041354$$7Person$$eCollaborator
000008331 8564_ $$9755c02b5-eed8-46c6-bcca-fb6addd34ca4$$s45660$$uhttps://digitalcollections.ohsu.edu/record/8331/files/ResearchWeek.2020.Stonebarger.Gail.pdf
000008331 905__ $$a/rest/prod/f4/75/2h/38/f4752h38h
000008331 980__ $$aResearch Week